| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LHA_2894 | LHA_2895 | LHA_2894 | LHA_2895 | Protein of unknown function; No homology to any previously reported sequences. | Homologs of previously reported genes of unknown function. | 0.803 |
| LHA_2894 | LHA_2896 | LHA_2894 | LHA_2896 | Protein of unknown function; No homology to any previously reported sequences. | Homologs of previously reported genes of unknown function. | 0.573 |
| LHA_2894 | ltaE | LHA_2894 | LHA_2893 | Protein of unknown function; No homology to any previously reported sequences. | Low specificity L-threonine aldolase. | 0.741 |
| LHA_2895 | LHA_2894 | LHA_2895 | LHA_2894 | Homologs of previously reported genes of unknown function. | Protein of unknown function; No homology to any previously reported sequences. | 0.803 |
| LHA_2895 | LHA_2896 | LHA_2895 | LHA_2896 | Homologs of previously reported genes of unknown function. | Homologs of previously reported genes of unknown function. | 0.573 |
| LHA_2895 | ltaE | LHA_2895 | LHA_2893 | Homologs of previously reported genes of unknown function. | Low specificity L-threonine aldolase. | 0.741 |
| LHA_2896 | LHA_2894 | LHA_2896 | LHA_2894 | Homologs of previously reported genes of unknown function. | Protein of unknown function; No homology to any previously reported sequences. | 0.573 |
| LHA_2896 | LHA_2895 | LHA_2896 | LHA_2895 | Homologs of previously reported genes of unknown function. | Homologs of previously reported genes of unknown function. | 0.573 |
| LHA_2896 | ltaE | LHA_2896 | LHA_2893 | Homologs of previously reported genes of unknown function. | Low specificity L-threonine aldolase. | 0.537 |
| gcvPA | gcvPB | LHA_0231 | LHA_0229 | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
| gcvPA | glyA | LHA_0231 | LHA_2325 | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.969 |
| gcvPA | kbl | LHA_0231 | LHA_0810 | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.908 |
| gcvPA | ltaE | LHA_0231 | LHA_2893 | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Low specificity L-threonine aldolase. | 0.927 |
| gcvPA | ydfG | LHA_0231 | LHA_1688 | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.568 |
| gcvPB | gcvPA | LHA_0229 | LHA_0231 | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
| gcvPB | glyA | LHA_0229 | LHA_2325 | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.989 |
| gcvPB | kbl | LHA_0229 | LHA_0810 | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.909 |
| gcvPB | ltaE | LHA_0229 | LHA_2893 | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | Low specificity L-threonine aldolase. | 0.928 |
| gcvPB | ydfG | LHA_0229 | LHA_1688 | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.703 |
| glyA | gcvPA | LHA_2325 | LHA_0231 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.969 |