Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IvgAVirulence protein; Function of strongly homologous gene; putative factor. (206 aa)    
Predicted Functional Partners:
icmW
IcmW.
    
 
 0.957
icmS
Component of Dot/Icm secretion system. Substrate recognition; Function of strongly homologous gene; factor.
    
 
 0.955
LHA_3180
Homologs of previously reported genes of unknown function.
    
   0.838
icmO/dotL
Component of Dot/Icm secretion system. ATPase; Function of strongly homologous gene; enzyme.
    
 
 0.816
LHA_2950
Homologs of previously reported genes of unknown function.
       0.736
feoB
Ferrous iron transport protein B; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
       0.736
LHA_2952
Ferrous iron transporter A.
       0.736
dotD
Component of the Dot/Icm secretion system. Lipoprotein; Function of strongly homologous gene; structure.
      
 0.635
dotC
Component of the Dot/Icm secretion system. Lipoprotein; Function of strongly homologous gene; membrane component.
      
 0.632
LHA_0527
Patatin-like phospholipase family protein.
    
   0.547
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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