STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kuConserved protein of unknown function; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (281 aa)    
Predicted Functional Partners:
LHA_0995
ATP-dependent DNA ligase.
 
  
 0.965
LHA_2010
DNA topoisomerase; Function of strongly homologous gene; enzyme.
 
    0.699
LHA_1491
ATP dependent DNA ligase; Function of strongly homologous gene; enzyme.
 
  
 0.577
LHA_3068
Glutamine amidotransferase.
       0.547
LHA_2513
Membrane protein of unknown function; No homology to any previously reported sequences.
 
     0.488
yhxC
Uncharacterized oxidoreductase yhxC.
 
     0.483
LHA_3070
Exported protein of unknown function; No homology to any previously reported sequences.
       0.482
LHA_3071
Isoaspartyl peptidase/L-asparaginase.
       0.465
LHA_3072
Putative cyanophycinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the peptidase S51 family.
       0.451
LHA_2303
Homologs of previously reported genes of unknown function.
 
    0.439
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.