Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
legPAstacin; Function of strongly homologous gene; enzyme. (260 aa)    
Predicted Functional Partners:
lapB
Conserved protein of unknown function; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.
    
 
 0.749
LHA_2602
Exported protein of unknown function [Collagen triple helix repeat]; No homology to any previously reported sequences.
  
     0.647
LHA_1301
Putative phosphoesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
  
     0.645
LHA_1000
5'-nucleotidase; Function of strongly homologous gene; enzyme.
 
 
   0.640
LHA_3259
Putative methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology.
       0.607
ftsK
DNA translocase ftsK.
    
 
 0.579
LHA_1268
Protein of unknown function [ankyrin repeat]; No homology to any previously reported sequences.
  
     0.572
LHA_2334
Exported protein of unknown function; No homology to any previously reported sequences.
    
 
 0.559
LHA_3258
Exported protein of unknown function; No homology to any previously reported sequences.
       0.547
LHA_3254
Protein of unknown function; No homology to any previously reported sequences.
  
   0.530
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.