node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHL50008.1 | SHL81926.1 | SAMN05660971_00761 | SAMN05660971_01444 | Aminomethyltransferase. | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 0.533 |
SHL50008.1 | SHL81959.1 | SAMN05660971_00761 | SAMN05660971_01445 | Aminomethyltransferase. | Aminomethyltransferase; Belongs to the GcvT family. | 0.753 |
SHL50008.1 | gcvH | SAMN05660971_00761 | SAMN05660971_00759 | Aminomethyltransferase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
SHL50008.1 | gcvP | SAMN05660971_00761 | SAMN05660971_00758 | Aminomethyltransferase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
SHL50008.1 | glyA | SAMN05660971_00761 | SAMN05660971_01863 | Aminomethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.993 |
SHL50008.1 | glyA-2 | SAMN05660971_00761 | SAMN05660971_01936 | Aminomethyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.993 |
SHL81926.1 | SHL50008.1 | SAMN05660971_01444 | SAMN05660971_00761 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Aminomethyltransferase. | 0.533 |
SHL81926.1 | SHL81959.1 | SAMN05660971_01444 | SAMN05660971_01445 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.821 |
SHL81926.1 | SHL99057.1 | SAMN05660971_01444 | SAMN05660971_01933 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.978 |
SHL81926.1 | SHM46151.1 | SAMN05660971_01444 | SAMN05660971_03044 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.979 |
SHL81926.1 | gcvH | SAMN05660971_01444 | SAMN05660971_00759 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.984 |
SHL81926.1 | gcvP | SAMN05660971_01444 | SAMN05660971_00758 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
SHL81926.1 | glyA | SAMN05660971_01444 | SAMN05660971_01863 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.822 |
SHL81926.1 | glyA-2 | SAMN05660971_01444 | SAMN05660971_01936 | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.822 |
SHL81959.1 | SHL50008.1 | SAMN05660971_01445 | SAMN05660971_00761 | Aminomethyltransferase; Belongs to the GcvT family. | Aminomethyltransferase. | 0.753 |
SHL81959.1 | SHL81926.1 | SAMN05660971_01445 | SAMN05660971_01444 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 0.821 |
SHL81959.1 | gcvH | SAMN05660971_01445 | SAMN05660971_00759 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
SHL81959.1 | gcvP | SAMN05660971_01445 | SAMN05660971_00758 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
SHL81959.1 | glyA | SAMN05660971_01445 | SAMN05660971_01863 | Aminomethyltransferase; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.828 |
SHL81959.1 | glyA-2 | SAMN05660971_01445 | SAMN05660971_01936 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.828 |