node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHL50008.1 | SHL99031.1 | SAMN05660971_00761 | SAMN05660971_01932 | Aminomethyltransferase. | Sarcosine oxidase subunit gamma. | 0.735 |
SHL50008.1 | SHL99084.1 | SAMN05660971_00761 | SAMN05660971_01934 | Aminomethyltransferase. | Sarcosine oxidase subunit delta. | 0.588 |
SHL50008.1 | folD | SAMN05660971_00761 | SAMN05660971_03160 | Aminomethyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.972 |
SHL50008.1 | gcvP | SAMN05660971_00761 | SAMN05660971_00758 | Aminomethyltransferase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
SHL50008.1 | glyA-2 | SAMN05660971_00761 | SAMN05660971_01936 | Aminomethyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.993 |
SHL50008.1 | purH | SAMN05660971_00761 | SAMN05660971_02687 | Aminomethyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.924 |
SHL50008.1 | purU-2 | SAMN05660971_00761 | SAMN05660971_01931 | Aminomethyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.904 |
SHL93864.1 | gcvP | SAMN05660971_01741 | SAMN05660971_00758 | Phosphoserine phosphatase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.435 |
SHL93864.1 | glyA-2 | SAMN05660971_01741 | SAMN05660971_01936 | Phosphoserine phosphatase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
SHL99031.1 | SHL50008.1 | SAMN05660971_01932 | SAMN05660971_00761 | Sarcosine oxidase subunit gamma. | Aminomethyltransferase. | 0.735 |
SHL99031.1 | SHL99057.1 | SAMN05660971_01932 | SAMN05660971_01933 | Sarcosine oxidase subunit gamma. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.999 |
SHL99031.1 | SHL99084.1 | SAMN05660971_01932 | SAMN05660971_01934 | Sarcosine oxidase subunit gamma. | Sarcosine oxidase subunit delta. | 0.999 |
SHL99031.1 | gcvP | SAMN05660971_01932 | SAMN05660971_00758 | Sarcosine oxidase subunit gamma. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.914 |
SHL99031.1 | glyA-2 | SAMN05660971_01932 | SAMN05660971_01936 | Sarcosine oxidase subunit gamma. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
SHL99031.1 | purU-2 | SAMN05660971_01932 | SAMN05660971_01931 | Sarcosine oxidase subunit gamma. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.884 |
SHL99057.1 | SHL99031.1 | SAMN05660971_01933 | SAMN05660971_01932 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Sarcosine oxidase subunit gamma. | 0.999 |
SHL99057.1 | SHL99084.1 | SAMN05660971_01933 | SAMN05660971_01934 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Sarcosine oxidase subunit delta. | 0.999 |
SHL99057.1 | folD | SAMN05660971_01933 | SAMN05660971_03160 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.726 |
SHL99057.1 | gcvP | SAMN05660971_01933 | SAMN05660971_00758 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
SHL99057.1 | glyA-2 | SAMN05660971_01933 | SAMN05660971_01936 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.989 |