| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MAE_04460 | MAE_04470 | MAE_04460 | MAE_04470 | Unknown protein. | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.714 |
| MAE_04460 | gyrA | MAE_04460 | MAE_04450 | Unknown protein. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.551 |
| MAE_04470 | MAE_04460 | MAE_04470 | MAE_04460 | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Unknown protein. | 0.714 |
| MAE_04470 | ahcY | MAE_04470 | MAE_50250 | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.900 |
| MAE_04470 | gyrA | MAE_04470 | MAE_04450 | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.512 |
| MAE_04470 | metK | MAE_04470 | MAE_45970 | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.904 |
| MAE_04470 | speH | MAE_04470 | MAE_40560 | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. | 0.900 |
| ahcY | MAE_04470 | MAE_50250 | MAE_04470 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.900 |
| ahcY | metK | MAE_50250 | MAE_45970 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.844 |
| gyrA | MAE_04460 | MAE_04450 | MAE_04460 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Unknown protein. | 0.551 |
| gyrA | MAE_04470 | MAE_04450 | MAE_04470 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.512 |
| metK | MAE_04470 | MAE_45970 | MAE_04470 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.904 |
| metK | ahcY | MAE_45970 | MAE_50250 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.844 |
| metK | speH | MAE_45970 | MAE_40560 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. | 0.933 |
| speH | MAE_04470 | MAE_40560 | MAE_04470 | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. | Cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.900 |
| speH | metK | MAE_40560 | MAE_45970 | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.933 |