MAE_59070 protein (Microcystis aeruginosa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

MAE_59070

Transposase. (159 aa)

Predicted Functional Partners:

MAE_59080

0.909

MAE_44550

0.815

MAE_27080

0.805

MAE_26910

0.800

MAE_29980

0.800

MAE_43300

0.800

MAE_33840

0.765

MAE_48690

0.763

MAE_33490

0.760

MAE_30000

0.538

Your Current Organism:

Microcystis aeruginosa

NCBI taxonomy Id: 449447
Other names: M. aeruginosa NIES-843, Microcystis aeruginosa NIES-843

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
MAE_26910	MAE_30000	Transposase.	Resolvase-like protein.	0.470
MAE_26910	MAE_59070	Transposase.	Transposase.	0.800
MAE_27080	MAE_30000	Transposase.	Resolvase-like protein.	0.461
MAE_27080	MAE_59070	Transposase.	Transposase.	0.805
MAE_29980	MAE_30000	Transposase.	Resolvase-like protein.	0.793
MAE_29980	MAE_59070	Transposase.	Transposase.	0.800
MAE_30000	MAE_26910	Resolvase-like protein.	Transposase.	0.470
MAE_30000	MAE_27080	Resolvase-like protein.	Transposase.	0.461
MAE_30000	MAE_29980	Resolvase-like protein.	Transposase.	0.793
MAE_30000	MAE_43300	Resolvase-like protein.	Transposase.	0.485
MAE_30000	MAE_44550	Resolvase-like protein.	Transposase.	0.483
MAE_30000	MAE_59070	Resolvase-like protein.	Transposase.	0.538
MAE_30000	MAE_59080	Resolvase-like protein.	Transposase.	0.499
MAE_33490	MAE_59070	Transposase.	Transposase.	0.760
MAE_33840	MAE_59070	Transposase.	Transposase.	0.765
MAE_43300	MAE_30000	Transposase.	Resolvase-like protein.	0.485
MAE_43300	MAE_59070	Transposase.	Transposase.	0.800
MAE_44550	MAE_30000	Transposase.	Resolvase-like protein.	0.483
MAE_44550	MAE_59070	Transposase.	Transposase.	0.815
MAE_48690	MAE_59070	Transposase.	Transposase.	0.763

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

14

PPI enrichment p-value:

6.66e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

7 of 24

1.66

2.63

8.03e-08

GO:0065008

Regulation of biological quality

4 of 23

1.44

1.25

0.00088

GO:0019538

Protein metabolic process

8 of 175

0.86

0.78

0.00016

GO:0044271

Cellular nitrogen compound biosynthetic process

8 of 253

0.7

0.55

0.0014

GO:1901566

Organonitrogen compound biosynthetic process

8 of 324

0.59

0.43

0.0058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

7 of 24

1.66

2.7

4.07e-08

GO:0002161

aminoacyl-tRNA editing activity

3 of 7

1.83

1.56

0.00058

GO:0016874

Ligase activity

8 of 83

1.18

1.46

9.28e-07

GO:0000049

tRNA binding

3 of 23

1.31

0.85

0.0098

GO:0005524

ATP binding

9 of 229

0.79

0.73

4.82e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:734

Mixed, incl. Serine protease, and Regulation of response to stimulus

4 of 6

2.02

2.05

6.95e-05

CL:280

Aminoacyl-tRNA biosynthesis, and Peptidase C26

3 of 14

1.53

0.91

0.0119

CL:283

Anticodon-binding domain of tRNA ligase, and glutamyl-tRNA aminoacylation

2 of 5

1.8

0.68

0.0491

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tai00970

Aminoacyl-tRNA biosynthesis

7 of 30

1.57

2.52

2.93e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 519

0.48

0.36

0.0092

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

7 of 26

1.63

2.74

1.24e-08

KW-0436

Ligase

9 of 60

1.37

2.23

1.29e-09

KW-0648

Protein biosynthesis

7 of 47

1.37

1.92

2.46e-07

KW-0067

ATP-binding

10 of 179

0.95

1.08

1.06e-07

KW-0963

Cytoplasm

8 of 218

0.76

0.66

0.00024

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13603

Leucyl-tRNA synthetase, Domain 2

3 of 3

2.2

1.58

0.0010

PF09334

tRNA synthetases class I (M)

3 of 4

2.07

1.55

0.0010

PF08264

Anticodon-binding domain of tRNA ligase

3 of 4

2.07

1.55

0.0010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009008

Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

3 of 3

2.2

1.34

0.0030

IPR002300

Aminoacyl-tRNA synthetase, class Ia

3 of 3

2.2

1.34

0.0030

IPR013155

Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding

3 of 4

2.07

1.32

0.0030

IPR009080

Aminoacyl-tRNA synthetase, class Ia, anticodon-binding

3 of 6

1.9

1.27

0.0031

IPR001412

Aminoacyl-tRNA synthetase, class I, conserved site

3 of 8

1.77

1.18

0.0040

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 3

2.02

0.82

0.0285

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