| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KRN96306.1 | KRN98801.1 | IV66_GL000800 | IV66_GL001785 | Adaptor protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.822 |
| KRN98290.1 | KRN98801.1 | IV66_GL002055 | IV66_GL001785 | Hypothetical protein. | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.828 |
| KRN98290.1 | clpP | IV66_GL002055 | IV66_GL000551 | Hypothetical protein. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.665 |
| KRN98290.1 | dnaK | IV66_GL002055 | IV66_GL000090 | Hypothetical protein. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.977 |
| KRN98290.1 | groL | IV66_GL002055 | IV66_GL000578 | Hypothetical protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.749 |
| KRN98290.1 | groS | IV66_GL002055 | IV66_GL000579 | Hypothetical protein. | Chaperonin GROES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.664 |
| KRN98290.1 | grpE | IV66_GL002055 | IV66_GL000089 | Hypothetical protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.911 |
| KRN98290.1 | hrcA | IV66_GL002055 | IV66_GL000088 | Hypothetical protein. | Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.632 |
| KRN98801.1 | KRN96306.1 | IV66_GL001785 | IV66_GL000800 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Adaptor protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | 0.822 |
| KRN98801.1 | KRN98290.1 | IV66_GL001785 | IV66_GL002055 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.828 |
| KRN98801.1 | clpP | IV66_GL001785 | IV66_GL000551 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.950 |
| KRN98801.1 | dnaJ | IV66_GL001785 | IV66_GL000091 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK a [...] | 0.852 |
| KRN98801.1 | dnaK | IV66_GL001785 | IV66_GL000090 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.944 |
| KRN98801.1 | groL | IV66_GL001785 | IV66_GL000578 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.727 |
| KRN98801.1 | groS | IV66_GL001785 | IV66_GL000579 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin GROES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.727 |
| KRN98801.1 | grpE | IV66_GL001785 | IV66_GL000089 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.752 |
| KRN98801.1 | hrcA | IV66_GL001785 | IV66_GL000088 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.678 |
| KRN98801.1 | infB | IV66_GL001785 | IV66_GL000084 | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | 0.655 |
| clpP | KRN98290.1 | IV66_GL000551 | IV66_GL002055 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Hypothetical protein. | 0.665 |
| clpP | KRN98801.1 | IV66_GL000551 | IV66_GL001785 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.950 |
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