| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lade_0365 | glmS | Lade_0365 | Lade_0368 | Hypothetical protein. | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.657 |
| Lade_0365 | smpB | Lade_0365 | Lade_0369 | Hypothetical protein. | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] | 0.477 |
| Lade_0365 | yciA | Lade_0365 | Lade_0366 | Hypothetical protein. | acyl-CoA thioester hydrolase. | 0.790 |
| Lade_0365 | yhgF | Lade_0365 | Lade_0367 | Hypothetical protein. | Transcriptional accessory protein. | 0.790 |
| Lade_1785 | yciA | Lade_1785 | Lade_0366 | Hypothetical protein. | acyl-CoA thioester hydrolase. | 0.547 |
| dhbF | fadB | Lade_2081 | Lade_0515 | Peptide synthetase, non-ribosomal; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxyacyl CoA dehydrogenase oxidoreductase protein. | 0.836 |
| dhbF | glmS | Lade_2081 | Lade_0368 | Peptide synthetase, non-ribosomal; Belongs to the ATP-dependent AMP-binding enzyme family. | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.454 |
| dhbF | sucC | Lade_2081 | Lade_1115 | Peptide synthetase, non-ribosomal; Belongs to the ATP-dependent AMP-binding enzyme family. | Succinyl CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.476 |
| dhbF | ybgC | Lade_2081 | Lade_1625 | Peptide synthetase, non-ribosomal; Belongs to the ATP-dependent AMP-binding enzyme family. | acyl-CoA thioesterase. | 0.850 |
| dhbF | yciA | Lade_2081 | Lade_0366 | Peptide synthetase, non-ribosomal; Belongs to the ATP-dependent AMP-binding enzyme family. | acyl-CoA thioester hydrolase. | 0.437 |
| dhbF | yfcX | Lade_2081 | Lade_1603 | Peptide synthetase, non-ribosomal; Belongs to the ATP-dependent AMP-binding enzyme family. | Enoyl CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.836 |
| fadB | dhbF | Lade_0515 | Lade_2081 | 3-hydroxyacyl CoA dehydrogenase oxidoreductase protein. | Peptide synthetase, non-ribosomal; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.836 |
| fadB | sucC | Lade_0515 | Lade_1115 | 3-hydroxyacyl CoA dehydrogenase oxidoreductase protein. | Succinyl CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.580 |
| fadB | ybgC | Lade_0515 | Lade_1625 | 3-hydroxyacyl CoA dehydrogenase oxidoreductase protein. | acyl-CoA thioesterase. | 0.776 |
| fadB | yciA | Lade_0515 | Lade_0366 | 3-hydroxyacyl CoA dehydrogenase oxidoreductase protein. | acyl-CoA thioester hydrolase. | 0.821 |
| fadB | yfcX | Lade_0515 | Lade_1603 | 3-hydroxyacyl CoA dehydrogenase oxidoreductase protein. | Enoyl CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.879 |
| glmS | Lade_0365 | Lade_0368 | Lade_0365 | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Hypothetical protein. | 0.657 |
| glmS | dhbF | Lade_0368 | Lade_2081 | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Peptide synthetase, non-ribosomal; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.454 |
| glmS | smpB | Lade_0368 | Lade_0369 | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] | 0.570 |
| glmS | yciA | Lade_0368 | Lade_0366 | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | acyl-CoA thioester hydrolase. | 0.682 |