Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ldhLeucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (357 aa)    
Predicted Functional Partners:
pdhB_1
2-oxoisovalerate dehydrogenase, E1 component, alpha and beta fusion.
 
 
 0.979
odpB
Pyruvate dehydrogenase E1 subunit beta.
  
 
  0.937
odpA
Pyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 
  0.935
Lade_0807
SAM-dependent O-methyltransferase.
       0.824
lly
4-hydroxyphenylpyruvate dioxygenase.
 
   
 0.798
sspA_1
Glutathione S-transferase (maleylacetoacetate isomerase).
 
     0.794
Lade_0809
Fumarylacetoacetate hydrolase.
  
    0.759
pta
Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase.
  
  
 0.720
ugpQ
Glycerophosphodiester phosphodiesterase, cytosolic.
  
    0.664
ugpB
Glycerol-3-phosphate-binding periplasmic protein precursor.
       0.662
Your Current Organism:
Legionella adelaidensis
NCBI taxonomy Id: 45056
Other names: ATCC 49625, CCUG 31231 A, CIP 103645, DSM 19888, L. adelaidensis, NCTC 12735
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