| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ascD | carA | Lade_1341 | Lade_0776 | NAD(P)H-flavin reductase. | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | 0.904 |
| ascD | carB | Lade_1341 | Lade_0178 | NAD(P)H-flavin reductase. | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | 0.924 |
| ascD | pyrB | Lade_1341 | Lade_1210 | NAD(P)H-flavin reductase. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.923 |
| ascD | pyrD | Lade_1341 | Lade_0239 | NAD(P)H-flavin reductase. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.985 |
| ascD | pyrE | Lade_1341 | Lade_1717 | NAD(P)H-flavin reductase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.925 |
| ascD | pyrF | Lade_1341 | Lade_0872 | NAD(P)H-flavin reductase. | Orotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.924 |
| carA | ascD | Lade_0776 | Lade_1341 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | NAD(P)H-flavin reductase. | 0.904 |
| carA | carB | Lade_0776 | Lade_0178 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | 0.999 |
| carA | pyrB | Lade_0776 | Lade_1210 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carA | pyrD | Lade_0776 | Lade_0239 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.943 |
| carA | pyrE | Lade_0776 | Lade_1717 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.928 |
| carA | pyrF | Lade_0776 | Lade_0872 | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | Orotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.920 |
| carB | ascD | Lade_0178 | Lade_1341 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | NAD(P)H-flavin reductase. | 0.924 |
| carB | carA | Lade_0178 | Lade_0776 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Carbamoyl phosphate synthase, small subunit; Belongs to the CarA family. | 0.999 |
| carB | pyrB | Lade_0178 | Lade_1210 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carB | pyrD | Lade_0178 | Lade_0239 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.975 |
| carB | pyrE | Lade_0178 | Lade_1717 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.956 |
| carB | pyrF | Lade_0178 | Lade_0872 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Orotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.942 |
| carB | pyrH | Lade_0178 | Lade_0631 | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.484 |
| pyrB | ascD | Lade_1210 | Lade_1341 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | NAD(P)H-flavin reductase. | 0.923 |