Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase. (415 aa)    
Predicted Functional Partners:
hppD
4-hydroxyphenylpyruvate dioxygenase.
 
 0.998
maiA
Glutathione S-transferase (maleylacetoacetate isomerase).
 
 
 0.963
Lgee_0453
Phenylalanine-4-hydroxylase.
 
  
 0.885
Lgee_0623
Fumarylacetoacetate hydrolase.
  
  
 0.883
phhA
Phenylalanine-4-hydroxylase.
 
  
 0.882
phs
Pterin 4 alpha carbinolamine dehydratase.
  
  
 0.711
Lgee_0206
Hypothetical protein.
       0.623
Lgee_0208
Hypothetical protein.
       0.570
ruvA
Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
     
 0.544
ruvC
Holliday junction resolvase; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
       0.504
Your Current Organism:
Legionella geestiana
NCBI taxonomy Id: 45065
Other names: ATCC 49504, CCUG 44893, CIP 105569, DSM 21217, L. geestiana, NCTC 12373
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