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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mvaAHydroxymethylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family. (431 aa)    
Predicted Functional Partners:
Lgee_1735
Mevalonate kinase.
 
 0.985
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.969
Lgee_1736
Mevalonate diphosphate decarboxylase.
 
  
 0.879
Lgee_0353
Hypothetical protein.
  
 
 0.864
Lgee_1591
Oxidoreductase.
   
  
 0.670
Lgee_1669
FAD dependent oxidoreductase.
   
  
 0.670
Lgee_1826
Kynurenine 3-monooxygenase.
   
  
 0.670
visC
Oxidoreductase with FAD/NAD(P)-binding domain protein.
   
  
 0.670
ubiH
2-octaprenyl-6-methoxyphenol hydroxylase.
   
  
 0.670
ssb-2
Single strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
       0.511
Your Current Organism:
Legionella geestiana
NCBI taxonomy Id: 45065
Other names: ATCC 49504, CCUG 44893, CIP 105569, DSM 21217, L. geestiana, NCTC 12373
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