Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mvaAHydroxymethylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family. (431 aa)    
Predicted Functional Partners:
Lgee_1735
Mevalonate kinase.
 
 0.983
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.977
Lgee_0353
Hypothetical protein.
  
 
 0.893
Lgee_1736
Mevalonate diphosphate decarboxylase.
 
  
 0.865
ssb-2
Single strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
       0.511
Lgee_1591
Oxidoreductase.
   
  
 0.481
Lgee_1669
FAD dependent oxidoreductase.
   
  
 0.481
Lgee_1826
Kynurenine 3-monooxygenase.
   
  
 0.481
visC
Oxidoreductase with FAD/NAD(P)-binding domain protein.
   
  
 0.481
ubiH
2-octaprenyl-6-methoxyphenol hydroxylase.
   
  
 0.481
Your Current Organism:
Legionella geestiana
NCBI taxonomy Id: 45065
Other names: ATCC 49504, CCUG 44893, CIP 105569, DSM 21217, L. geestiana, NCTC 12373
Server load: low (22%) [HD]