| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lgee_0552 | glyA | Lgee_0552 | Lgee_1197 | Inosine 5'-monophosphate dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.550 |
| Lgee_0552 | guaA | Lgee_0552 | Lgee_1060 | Inosine 5'-monophosphate dehydrogenase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.998 |
| Lgee_0552 | guaB | Lgee_0552 | Lgee_1059 | Inosine 5'-monophosphate dehydrogenase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.920 |
| Lgee_0552 | ppt | Lgee_0552 | Lgee_2081 | Inosine 5'-monophosphate dehydrogenase. | Hypoxanthine-guanine phosphoribosyltransferase. | 0.919 |
| Lgee_0552 | purA | Lgee_0552 | Lgee_0441 | Inosine 5'-monophosphate dehydrogenase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.989 |
| Lgee_0552 | purB | Lgee_0552 | Lgee_1587 | Inosine 5'-monophosphate dehydrogenase. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.798 |
| Lgee_0552 | rdgB | Lgee_0552 | Lgee_0573 | Inosine 5'-monophosphate dehydrogenase. | Deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.927 |
| asnB | guaA | Lgee_1604 | Lgee_1060 | Asparagine synthetase, glutamine-hydrolyzing. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.483 |
| asnB | nadB | Lgee_1604 | Lgee_1588 | Asparagine synthetase, glutamine-hydrolyzing. | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | 0.908 |
| asnB | purA | Lgee_1604 | Lgee_0441 | Asparagine synthetase, glutamine-hydrolyzing. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.914 |
| asnB | pyrB | Lgee_1604 | Lgee_1270 | Asparagine synthetase, glutamine-hydrolyzing. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.926 |
| glyA | Lgee_0552 | Lgee_1197 | Lgee_0552 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine 5'-monophosphate dehydrogenase. | 0.550 |
| glyA | guaA | Lgee_1197 | Lgee_1060 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.721 |
| glyA | guaB | Lgee_1197 | Lgee_1059 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.550 |
| glyA | purA | Lgee_1197 | Lgee_0441 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.915 |
| glyA | purB | Lgee_1197 | Lgee_1587 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.890 |
| guaA | Lgee_0552 | Lgee_1060 | Lgee_0552 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine 5'-monophosphate dehydrogenase. | 0.998 |
| guaA | asnB | Lgee_1060 | Lgee_1604 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Asparagine synthetase, glutamine-hydrolyzing. | 0.483 |
| guaA | glyA | Lgee_1060 | Lgee_1197 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.721 |
| guaA | guaB | Lgee_1060 | Lgee_1059 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
