| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| mfd_1 | mfd_2 | Lgee_0534 | Lgee_1535 | Transcription-repair coupling factor. | Transcription-repair coupling factor. | 0.974 |
| mfd_1 | mutL | Lgee_0534 | Lgee_2204 | Transcription-repair coupling factor. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.570 |
| mfd_1 | polA | Lgee_0534 | Lgee_1919 | Transcription-repair coupling factor. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.556 |
| mfd_1 | pth | Lgee_0534 | Lgee_1452 | Transcription-repair coupling factor. | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.602 |
| mfd_1 | rpoA | Lgee_0534 | Lgee_1313 | Transcription-repair coupling factor. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.825 |
| mfd_1 | rpoB | Lgee_0534 | Lgee_1107 | Transcription-repair coupling factor. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.856 |
| mfd_1 | rpoC | Lgee_0534 | Lgee_1106 | Transcription-repair coupling factor. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.859 |
| mfd_1 | rpoZ | Lgee_0534 | Lgee_0795 | Transcription-repair coupling factor. | RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.825 |
| mfd_1 | tilS | Lgee_0534 | Lgee_0912 | Transcription-repair coupling factor. | Cell cycle protein MesJ; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.574 |
| mfd_1 | uvrA | Lgee_0534 | Lgee_1491 | Transcription-repair coupling factor. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.853 |
| mfd_2 | mfd_1 | Lgee_1535 | Lgee_0534 | Transcription-repair coupling factor. | Transcription-repair coupling factor. | 0.974 |
| mfd_2 | mutL | Lgee_1535 | Lgee_2204 | Transcription-repair coupling factor. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.521 |
| mfd_2 | polA | Lgee_1535 | Lgee_1919 | Transcription-repair coupling factor. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.517 |
| mfd_2 | pth | Lgee_1535 | Lgee_1452 | Transcription-repair coupling factor. | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. | 0.602 |
| mfd_2 | rpoA | Lgee_1535 | Lgee_1313 | Transcription-repair coupling factor. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.825 |
| mfd_2 | rpoB | Lgee_1535 | Lgee_1107 | Transcription-repair coupling factor. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.856 |
| mfd_2 | rpoC | Lgee_1535 | Lgee_1106 | Transcription-repair coupling factor. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.852 |
| mfd_2 | rpoZ | Lgee_1535 | Lgee_0795 | Transcription-repair coupling factor. | RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.825 |
| mfd_2 | tilS | Lgee_1535 | Lgee_0912 | Transcription-repair coupling factor. | Cell cycle protein MesJ; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.572 |
| mfd_2 | uvrA | Lgee_1535 | Lgee_1491 | Transcription-repair coupling factor. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.920 |