| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpA | clpP | Lgee_1575 | Lgee_0785 | ATP binding protease component ClpA; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.930 |
| clpA | dnaK | Lgee_1575 | Lgee_1429 | ATP binding protease component ClpA; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.968 |
| clpA | groES | Lgee_1575 | Lgee_1184 | ATP binding protease component ClpA; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.788 |
| clpA | grpE | Lgee_1575 | Lgee_1430 | ATP binding protease component ClpA; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.896 |
| clpA | lon | Lgee_1575 | Lgee_0783 | ATP binding protease component ClpA; Belongs to the ClpA/ClpB family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.783 |
| clpB_1 | clpB_2 | Lgee_1529 | Lgee_1536 | Endopeptidase Clp ATP-binding subunit B; Belongs to the ClpA/ClpB family. | Endopeptidase Clp ATP-binding subunit B. | 0.976 |
| clpB_1 | clpP | Lgee_1529 | Lgee_0785 | Endopeptidase Clp ATP-binding subunit B; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.930 |
| clpB_1 | dnaK | Lgee_1529 | Lgee_1429 | Endopeptidase Clp ATP-binding subunit B; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.968 |
| clpB_1 | groES | Lgee_1529 | Lgee_1184 | Endopeptidase Clp ATP-binding subunit B; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.788 |
| clpB_1 | grpE | Lgee_1529 | Lgee_1430 | Endopeptidase Clp ATP-binding subunit B; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.896 |
| clpB_1 | lon | Lgee_1529 | Lgee_0783 | Endopeptidase Clp ATP-binding subunit B; Belongs to the ClpA/ClpB family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.783 |
| clpB_2 | clpB_1 | Lgee_1536 | Lgee_1529 | Endopeptidase Clp ATP-binding subunit B. | Endopeptidase Clp ATP-binding subunit B; Belongs to the ClpA/ClpB family. | 0.976 |
| clpB_2 | clpP | Lgee_1536 | Lgee_0785 | Endopeptidase Clp ATP-binding subunit B. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.938 |
| clpB_2 | dnaK | Lgee_1536 | Lgee_1429 | Endopeptidase Clp ATP-binding subunit B. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.968 |
| clpB_2 | groES | Lgee_1536 | Lgee_1184 | Endopeptidase Clp ATP-binding subunit B. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.788 |
| clpB_2 | grpE | Lgee_1536 | Lgee_1430 | Endopeptidase Clp ATP-binding subunit B. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.896 |
| clpB_2 | lon | Lgee_1536 | Lgee_0783 | Endopeptidase Clp ATP-binding subunit B. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.783 |
| clpP | clpA | Lgee_0785 | Lgee_1575 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP binding protease component ClpA; Belongs to the ClpA/ClpB family. | 0.930 |
| clpP | clpB_1 | Lgee_0785 | Lgee_1529 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Endopeptidase Clp ATP-binding subunit B; Belongs to the ClpA/ClpB family. | 0.930 |
| clpP | clpB_2 | Lgee_0785 | Lgee_1536 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Endopeptidase Clp ATP-binding subunit B. | 0.938 |
STRING v12.5 is now available!
