| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lgee_1599 | glyA | Lgee_1599 | Lgee_1197 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.970 |
| Lgee_1599 | trpA | Lgee_1599 | Lgee_0994 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.914 |
| Lgee_1599 | trpB | Lgee_1599 | Lgee_0995 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| glyA | Lgee_1599 | Lgee_1197 | Lgee_1599 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.970 |
| glyA | pabB | Lgee_1197 | Lgee_0654 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Para-aminobenzoate synthase component I. | 0.433 |
| glyA | trpA | Lgee_1197 | Lgee_0994 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.929 |
| glyA | trpB | Lgee_1197 | Lgee_0995 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.923 |
| glyA | trpE | Lgee_1197 | Lgee_1629 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Anthranilate synthase. | 0.495 |
| glyA | trpG | Lgee_1197 | Lgee_0820 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Anthranilate synthase component II. | 0.415 |
| lgt | trpA | Lgee_1930 | Lgee_0994 | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.915 |
| lgt | trpB | Lgee_1930 | Lgee_0995 | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.897 |
| pabB | glyA | Lgee_0654 | Lgee_1197 | Para-aminobenzoate synthase component I. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.433 |
| pabB | trpA | Lgee_0654 | Lgee_0994 | Para-aminobenzoate synthase component I. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.970 |
| pabB | trpB | Lgee_0654 | Lgee_0995 | Para-aminobenzoate synthase component I. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.966 |
| pabB | trpC | Lgee_0654 | Lgee_1648 | Para-aminobenzoate synthase component I. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.997 |
| pabB | trpD | Lgee_0654 | Lgee_1647 | Para-aminobenzoate synthase component I. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.995 |
| pabB | trpE | Lgee_0654 | Lgee_1629 | Para-aminobenzoate synthase component I. | Anthranilate synthase. | 0.989 |
| pabB | trpF | Lgee_0654 | Lgee_0996 | Para-aminobenzoate synthase component I. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.956 |
| pabB | trpG | Lgee_0654 | Lgee_0820 | Para-aminobenzoate synthase component I. | Anthranilate synthase component II. | 0.999 |
| trpA | Lgee_1599 | Lgee_0994 | Lgee_1599 | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.914 |
