acsA_2 protein (Legionella geestiana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

acsA_2

acetyl-CoA synthetase. (528 aa)

Predicted Functional Partners:

acsA_1

0.976

fadB

0.943

yfcX

0.943

atoB

0.933

yfcY

0.924

mvaB

0.923

phbB

0.900

thiD

0.628

thiDE

0.626

thiM

0.608

Your Current Organism:

Legionella geestiana

NCBI taxonomy Id: 45065
Other names: ATCC 49504, CCUG 44893, CIP 105569, DSM 21217, L. geestiana, NCTC 12373

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acsA_1	acsA_2	Lgee_0898	Lgee_1670	acetyl-CoA synthetase.	acetyl-CoA synthetase.	0.976
acsA_1	atoB	Lgee_0898	Lgee_0904	acetyl-CoA synthetase.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.766
acsA_1	fadB	Lgee_0898	Lgee_0211	acetyl-CoA synthetase.	3-hydroxyacyl CoA dehydrogenase oxidoreductase protein.	0.458
acsA_1	mvaB	Lgee_0898	Lgee_0899	acetyl-CoA synthetase.	hydroxymethylglutaryl-CoA lyase.	0.810
acsA_1	yfcX	Lgee_0898	Lgee_2128	acetyl-CoA synthetase.	Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.458
acsA_2	acsA_1	Lgee_1670	Lgee_0898	acetyl-CoA synthetase.	acetyl-CoA synthetase.	0.976
acsA_2	atoB	Lgee_1670	Lgee_0904	acetyl-CoA synthetase.	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.933
acsA_2	fadB	Lgee_1670	Lgee_0211	acetyl-CoA synthetase.	3-hydroxyacyl CoA dehydrogenase oxidoreductase protein.	0.943
acsA_2	mvaB	Lgee_1670	Lgee_0899	acetyl-CoA synthetase.	hydroxymethylglutaryl-CoA lyase.	0.923
acsA_2	phbB	Lgee_1670	Lgee_0883	acetyl-CoA synthetase.	Acetyoacetyl CoA reductase.	0.900
acsA_2	thiD	Lgee_1670	Lgee_1673	acetyl-CoA synthetase.	Bifunctional hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase.	0.628
acsA_2	thiDE	Lgee_1670	Lgee_1671	acetyl-CoA synthetase.	Phosphomethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.626
acsA_2	thiM	Lgee_1670	Lgee_1672	acetyl-CoA synthetase.	Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.	0.608
acsA_2	yfcX	Lgee_1670	Lgee_2128	acetyl-CoA synthetase.	Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.943
acsA_2	yfcY	Lgee_1670	Lgee_2129	acetyl-CoA synthetase.	beta-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.924
atoB	acsA_1	Lgee_0904	Lgee_0898	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA synthetase.	0.766
atoB	acsA_2	Lgee_0904	Lgee_1670	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA synthetase.	0.933
atoB	fadB	Lgee_0904	Lgee_0211	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxyacyl CoA dehydrogenase oxidoreductase protein.	0.999
atoB	mvaB	Lgee_0904	Lgee_0899	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	hydroxymethylglutaryl-CoA lyase.	0.987
atoB	phbB	Lgee_0904	Lgee_0883	acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyoacetyl CoA reductase.	0.932