Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Lgee_1941Pteridine reductase. (238 aa)    
Predicted Functional Partners:
folA
Dihydrofolate reductase FolA; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.907
Lgee_0453
Phenylalanine-4-hydroxylase.
    
  0.903
phhA
Phenylalanine-4-hydroxylase.
    
  0.903
Lgee_2122
Acetyltransferase.
  
 
 0.850
Lgee_1939
6-pyruvoyl tetrahydropterin synthase.
    
  0.806
Lgee_1732
Peptide synthetase, non-ribosomal.
  
 
 0.804
priA
Primosomal protein N' (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.
       0.766
Lgee_1940
Hypothetical protein.
       0.766
Lgee_0245
Oxidoreductase dehydrogenase, short chain; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
     0.664
yueD_2
Sepiapterin reductase.
  
     0.591
Your Current Organism:
Legionella geestiana
NCBI taxonomy Id: 45065
Other names: ATCC 49504, CCUG 44893, CIP 105569, DSM 21217, L. geestiana, NCTC 12373
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.