STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
bphI4-hydroxy-2-oxovalerate aldolase. (282 aa)    
Predicted Functional Partners:
dat
Aminodeoxychorismate lyase.
 
 0.877
mccA
Acyl CoA carboxylase subunit alpha.
  
 
 0.845
budB_2
Acetolactate synthase; Belongs to the TPP enzyme family.
 
 
 0.777
Lgra_2054
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.737
pta
Phosphate acetyl/butaryl transferase.
   
 
 0.728
budB_1
Acetolactate synthase; Belongs to the TPP enzyme family.
  
 
 0.710
Lgra_0544
Polyketide synthase.
  
 
 0.684
pdhB_2
Pyruvate/2-oxoglutarate dehydrogenase subunit E1.
  
 
 0.679
edd
6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family.
 
 
 0.657
succ
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 0.652
Your Current Organism:
Legionella gratiana
NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412
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