Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ldhLeucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (357 aa)    
Predicted Functional Partners:
pdhB_2
Pyruvate/2-oxoglutarate dehydrogenase subunit E1.
 
 
 0.978
odpA
Pyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
  
 
 0.928
Lgra_2054
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
  
 
 0.917
odpB
Pyruvate dehydrogenase E1 subunit beta.
  
 
 0.904
putA
Bifunctional PutA protein (proline dehydrogenase/ delta-1-pyrroline-5-carboxylate dehydrogenase); Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
  
 
 0.883
pta
Phosphate acetyl/butaryl transferase.
  
  
 0.850
Lgra_0777
O-methyltransferase.
       0.825
gltB_1
Glutamate synthase; Belongs to the glutamate synthase family.
 
 0.752
pksJ_2
Polyketide synthase module; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.751
pksJ_1
Polyketide synthase, type I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
   
 0.751
Your Current Organism:
Legionella gratiana
NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412
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