Hgd protein (Legionella gratiana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

Hgd

3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (298 aa)

Predicted Functional Partners:

echA8

0.994

mmsA

0.981

acsB

0.976

pta

0.867

ywdH

0.866

prpC

0.860

odp

0.855

gbsA

0.783

gabT

0.737

garR

0.691

Your Current Organism:

Legionella gratiana

NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hgd	acsB	Lgra_1469	Lgra_1468	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.976
Hgd	echA8	Lgra_1469	Lgra_2962	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	enoyl-CoA hydratase.	0.994
Hgd	gabT	Lgra_1469	Lgra_1491	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.737
Hgd	garR	Lgra_1469	Lgra_2075	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	3-hydroxyisobutyrate dehydrogenase.	0.691
Hgd	gbsA	Lgra_1469	Lgra_1490	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Glycine betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.783
Hgd	mmsA	Lgra_1469	Lgra_1470	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.981
Hgd	odp	Lgra_1469	Lgra_2127	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Branched-chain alpha-keto acid dehydrogenase subunit E2.	0.855
Hgd	prpC	Lgra_1469	Lgra_2093	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	2-methylcitrate synthase; Belongs to the citrate synthase family.	0.860
Hgd	pta	Lgra_1469	Lgra_2415	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Phosphate acetyl/butaryl transferase.	0.867
Hgd	ywdH	Lgra_1469	Lgra_2315	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.866
acsB	Hgd	Lgra_1468	Lgra_1469	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.976
acsB	gabT	Lgra_1468	Lgra_1491	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.804
acsB	garR	Lgra_1468	Lgra_2075	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyisobutyrate dehydrogenase.	0.565
acsB	gbsA	Lgra_1468	Lgra_1490	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Glycine betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.780
acsB	mmsA	Lgra_1468	Lgra_1470	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.957
acsB	odp	Lgra_1468	Lgra_2127	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Branched-chain alpha-keto acid dehydrogenase subunit E2.	0.855
acsB	prpC	Lgra_1468	Lgra_2093	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	2-methylcitrate synthase; Belongs to the citrate synthase family.	0.895
acsB	pta	Lgra_1468	Lgra_2415	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Phosphate acetyl/butaryl transferase.	0.920
acsB	ywdH	Lgra_1468	Lgra_2315	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.861
echA8	Hgd	Lgra_2962	Lgra_1469	enoyl-CoA hydratase.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.994