Lgra_1964 protein (Legionella gratiana) - STRING interaction network

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Lgra_1964

NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (394 aa)

Predicted Functional Partners:

mdh

0.896

fumC

0.869

frmC

0.869

sfcA_1

0.861

sfcA_2

0.861

maeB

0.861

Lgra_2054

0.847

capP

0.845

pta

0.763

purU

0.737

Your Current Organism:

Legionella gratiana

NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lgra_1964	Lgra_2054	Lgra_1964	Lgra_2054	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.847
Lgra_1964	capP	Lgra_1964	Lgra_0953	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	0.845
Lgra_1964	frmC	Lgra_1964	Lgra_2325	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.869
Lgra_1964	fumC	Lgra_1964	Lgra_1163	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.869
Lgra_1964	maeB	Lgra_1964	Lgra_2240	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	NADP-dependent malic enzyme.	0.861
Lgra_1964	mdh	Lgra_1964	Lgra_2650	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.896
Lgra_1964	pta	Lgra_1964	Lgra_2415	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Phosphate acetyl/butaryl transferase.	0.763
Lgra_1964	purU	Lgra_1964	Lgra_0532	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).	0.737
Lgra_1964	sfcA_1	Lgra_1964	Lgra_0913	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Malate dehydrogenase.	0.861
Lgra_1964	sfcA_2	Lgra_1964	Lgra_1735	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Malate oxidoreductase.	0.861
Lgra_2054	Lgra_1964	Lgra_2054	Lgra_1964	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.847
Lgra_2054	fumC	Lgra_2054	Lgra_1163	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.847
Lgra_2054	maeB	Lgra_2054	Lgra_2240	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	NADP-dependent malic enzyme.	0.882
Lgra_2054	mdh	Lgra_2054	Lgra_2650	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.966
Lgra_2054	pta	Lgra_2054	Lgra_2415	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Phosphate acetyl/butaryl transferase.	0.954
Lgra_2054	sfcA_1	Lgra_2054	Lgra_0913	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Malate dehydrogenase.	0.882
Lgra_2054	sfcA_2	Lgra_2054	Lgra_1735	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Malate oxidoreductase.	0.882
capP	Lgra_1964	Lgra_0953	Lgra_1964	Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.845
capP	mdh	Lgra_0953	Lgra_2650	Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.904
capP	pta	Lgra_0953	Lgra_2415	Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	Phosphate acetyl/butaryl transferase.	0.492

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