STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
yvgNOxidoreductase,aldo/keto reductase family. (285 aa)    
Predicted Functional Partners:
Lgra_1022
Serine protein kinase.
   
    0.793
frmA
Alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
   
 0.698
pksJ_2
Polyketide synthase module; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 0.651
pksJ_1
Polyketide synthase, type I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
 0.651
pksM
Polyketide synthase.
  
 0.651
adhT
Alcohol dehydrogenase.
  
 
 0.628
yahK
Zinc-type alcohol dehydrogenase-like protein.
  
 
 0.628
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
   
 0.619
Lgra_1964
NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
 
 0.611
tdh
Threonine(-3-)dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family.
  
 0.590
Your Current Organism:
Legionella gratiana
NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412
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