htpX_1 protein (Legionella gratiana) - STRING interaction network

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htpX_1

M48 family peptidase; Belongs to the peptidase M48B family. (296 aa)

Predicted Functional Partners:

ftsH_1

0.641

ftsH_2

0.641

ndh_1

0.581

yccA

0.484

grpE

0.459

Lgra_2252

0.455

mdcA

0.405

Your Current Organism:

Legionella gratiana

NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lgra_2252	htpX_1	Lgra_2252	Lgra_2253	Sulfite exporter TauE/SafE.	M48 family peptidase; Belongs to the peptidase M48B family.	0.455
ftsH_1	grpE	Lgra_1006	Lgra_2295	Cell division protease ftsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Heat-shock protein GrpE(HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sever [...]	0.445
ftsH_1	htpX_1	Lgra_1006	Lgra_2253	Cell division protease ftsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	M48 family peptidase; Belongs to the peptidase M48B family.	0.641
ftsH_2	grpE	Lgra_1921	Lgra_2295	Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	Heat-shock protein GrpE(HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sever [...]	0.445
ftsH_2	htpX_1	Lgra_1921	Lgra_2253	Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	M48 family peptidase; Belongs to the peptidase M48B family.	0.641
grpE	ftsH_1	Lgra_2295	Lgra_1006	Heat-shock protein GrpE(HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sever [...]	Cell division protease ftsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.445
grpE	ftsH_2	Lgra_2295	Lgra_1921	Heat-shock protein GrpE(HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sever [...]	Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.445
grpE	htpX_1	Lgra_2295	Lgra_2253	Heat-shock protein GrpE(HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sever [...]	M48 family peptidase; Belongs to the peptidase M48B family.	0.459
htpX_1	Lgra_2252	Lgra_2253	Lgra_2252	M48 family peptidase; Belongs to the peptidase M48B family.	Sulfite exporter TauE/SafE.	0.455
htpX_1	ftsH_1	Lgra_2253	Lgra_1006	M48 family peptidase; Belongs to the peptidase M48B family.	Cell division protease ftsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.641
htpX_1	ftsH_2	Lgra_2253	Lgra_1921	M48 family peptidase; Belongs to the peptidase M48B family.	Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.641
htpX_1	grpE	Lgra_2253	Lgra_2295	M48 family peptidase; Belongs to the peptidase M48B family.	Heat-shock protein GrpE(HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sever [...]	0.459
htpX_1	mdcA	Lgra_2253	Lgra_2255	M48 family peptidase; Belongs to the peptidase M48B family.	Malonate decarboxylase subunit alpha.	0.405
htpX_1	ndh_1	Lgra_2253	Lgra_2254	M48 family peptidase; Belongs to the peptidase M48B family.	Respiratory NADH dehydrogenase 2/cupric reductase.	0.581
htpX_1	yccA	Lgra_2253	Lgra_2052	M48 family peptidase; Belongs to the peptidase M48B family.	Carrier/transport protein; Belongs to the BI1 family.	0.484
mdcA	htpX_1	Lgra_2255	Lgra_2253	Malonate decarboxylase subunit alpha.	M48 family peptidase; Belongs to the peptidase M48B family.	0.405
mdcA	ndh_1	Lgra_2255	Lgra_2254	Malonate decarboxylase subunit alpha.	Respiratory NADH dehydrogenase 2/cupric reductase.	0.525
ndh_1	htpX_1	Lgra_2254	Lgra_2253	Respiratory NADH dehydrogenase 2/cupric reductase.	M48 family peptidase; Belongs to the peptidase M48B family.	0.581
ndh_1	mdcA	Lgra_2254	Lgra_2255	Respiratory NADH dehydrogenase 2/cupric reductase.	Malonate decarboxylase subunit alpha.	0.525
yccA	htpX_1	Lgra_2052	Lgra_2253	Carrier/transport protein; Belongs to the BI1 family.	M48 family peptidase; Belongs to the peptidase M48B family.	0.484