Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Lgra_2349Hypothetical protein. (212 aa)    
Predicted Functional Partners:
bvgS
Sensory box histidine kinase/response regulator.
    
 0.763
arcB_3
Sensory histidine-kinase / response regulator.
    
 0.763
letS
Legionella transmission sensor LetS.
     
 0.707
divK
Polar-differentiation response regulator DivK.
     
 0.608
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
   
 
 0.607
metB
Cystathionine beta-lyase.
  
 
 0.601
Lgra_2348
Bestrophin, RFP-TM, chloride channel.
       0.490
bacD_2
Phosphoribosylglycinamide synthetase ATP-grasp (A) domain protein.
  
 
 0.467
lysAC
Diaminopimelate decarboxylase, aspartate kinase (fusion of lysA and lysC); Belongs to the Orn/Lys/Arg decarboxylase class-II family.
     
 0.441
cysK_1
Cystathionine beta-synthase.
  
 
 0.436
Your Current Organism:
Legionella gratiana
NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412
Server load: medium (44%) [HD]