plaA protein (Legionella gratiana) - STRING interaction network

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Score

plaA

Lysophospholipase A. (313 aa)

Predicted Functional Partners:

lapB

0.731

sdhA_2

0.725

lspD

0.694

lspK

0.680

lspF

0.667

pilD

0.665

lspI

0.635

lssX

0.634

lipA

0.634

plaC

0.481

Your Current Organism:

Legionella gratiana

NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
lapB	lipA	Lgra_0280	Lgra_1839	Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.707
lapB	lssX	Lgra_0280	Lgra_0314	Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.	Legionella secretion system protein X; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.	0.728
lapB	plaA	Lgra_0280	Lgra_2677	Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.	Lysophospholipase A.	0.731
lapB	plaC	Lgra_0280	Lgra_1060	Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.	Lysophospholipase A.	0.734
lapB	sdhA_2	Lgra_0280	Lgra_0642	Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.	Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.	0.738
lipA	lapB	Lgra_1839	Lgra_0280	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.	0.707
lipA	lssX	Lgra_1839	Lgra_0314	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Legionella secretion system protein X; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.	0.998
lipA	plaA	Lgra_1839	Lgra_2677	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Lysophospholipase A.	0.634
lipA	plaC	Lgra_1839	Lgra_1060	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Lysophospholipase A.	0.676
lipA	sdhA_2	Lgra_1839	Lgra_0642	Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.	0.716
lspD	lspF	Lgra_1204	Lgra_3234	Type II protein secretion LspD.	Type II secretory pathway protein LspF.	0.932
lspD	lspI	Lgra_1204	Lgra_3237	Type II protein secretion LspD.	Type II secretory pathway protein LspI.	0.939
lspD	lspK	Lgra_1204	Lgra_3239	Type II protein secretion LspD.	Type II secretory pathway protein LspK.	0.933
lspD	pilD	Lgra_1204	Lgra_2067	Type II protein secretion LspD.	Type 4 prepilin-like proteins leader peptide processing enzyme; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	0.743
lspD	plaA	Lgra_1204	Lgra_2677	Type II protein secretion LspD.	Lysophospholipase A.	0.694
lspF	lspD	Lgra_3234	Lgra_1204	Type II secretory pathway protein LspF.	Type II protein secretion LspD.	0.932
lspF	lspI	Lgra_3234	Lgra_3237	Type II secretory pathway protein LspF.	Type II secretory pathway protein LspI.	0.970
lspF	lspK	Lgra_3234	Lgra_3239	Type II secretory pathway protein LspF.	Type II secretory pathway protein LspK.	0.952
lspF	pilD	Lgra_3234	Lgra_2067	Type II secretory pathway protein LspF.	Type 4 prepilin-like proteins leader peptide processing enzyme; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	0.944
lspF	plaA	Lgra_3234	Lgra_2677	Type II secretory pathway protein LspF.	Lysophospholipase A.	0.667