pepA protein (Legionella gratiana) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

pepA

Leucine aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (483 aa)

Predicted Functional Partners:

Lgra_2857

0.893

pepN_1

0.891

gshB

0.890

holC

0.887

pepA_1

0.884

ggt

0.880

pepN_2

0.867

Lgra_1384

0.861

glyA

0.858

metB

0.851

Your Current Organism:

Legionella gratiana

NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lgra_1384	metB	Lgra_1384	Lgra_2912	Aspartate aminotransferase.	Cystathionine beta-lyase.	0.885
Lgra_1384	pepA	Lgra_1384	Lgra_2856	Aspartate aminotransferase.	Leucine aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.861
Lgra_1384	pepA_1	Lgra_1384	Lgra_2852	Aspartate aminotransferase.	Aminopeptidase; Belongs to the peptidase M17 family.	0.861
Lgra_1384	pepN_1	Lgra_1384	Lgra_1021	Aspartate aminotransferase.	Aminopeptidase.	0.849
Lgra_1384	pepN_2	Lgra_1384	Lgra_2061	Aspartate aminotransferase.	Aminopeptidase.	0.835
Lgra_2857	glyA	Lgra_2857	Lgra_2893	Hypothetical protein.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.484
Lgra_2857	holC	Lgra_2857	Lgra_2855	Hypothetical protein.	DNA polymerase III, chi subunit.	0.843
Lgra_2857	pepA	Lgra_2857	Lgra_2856	Hypothetical protein.	Leucine aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.893
ggt	gshB	Lgra_0627	Lgra_1652	Gamma-glutamyltranspeptidase.	Glutathione synthetase; Belongs to the prokaryotic GSH synthase family.	0.899
ggt	pepA	Lgra_0627	Lgra_2856	Gamma-glutamyltranspeptidase.	Leucine aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.880
ggt	pepA_1	Lgra_0627	Lgra_2852	Gamma-glutamyltranspeptidase.	Aminopeptidase; Belongs to the peptidase M17 family.	0.880
ggt	pepN_1	Lgra_0627	Lgra_1021	Gamma-glutamyltranspeptidase.	Aminopeptidase.	0.849
ggt	pepN_2	Lgra_0627	Lgra_2061	Gamma-glutamyltranspeptidase.	Aminopeptidase.	0.849
glyA	Lgra_2857	Lgra_2893	Lgra_2857	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Hypothetical protein.	0.484
glyA	gshB	Lgra_2893	Lgra_1652	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glutathione synthetase; Belongs to the prokaryotic GSH synthase family.	0.859
glyA	pepA	Lgra_2893	Lgra_2856	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Leucine aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.858
glyA	pepA_1	Lgra_2893	Lgra_2852	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Aminopeptidase; Belongs to the peptidase M17 family.	0.858
glyA	pepN_1	Lgra_2893	Lgra_1021	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Aminopeptidase.	0.890
glyA	pepN_2	Lgra_2893	Lgra_2061	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Aminopeptidase.	0.886
gshB	ggt	Lgra_1652	Lgra_0627	Glutathione synthetase; Belongs to the prokaryotic GSH synthase family.	Gamma-glutamyltranspeptidase.	0.899

page 1 of 4

Server load: medium (48%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About