mutY protein (Legionella gratiana) - STRING interaction network

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Score

mutY

A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (377 aa)

Predicted Functional Partners:

dnaN

0.861

exoA

0.737

xthA

0.737

Lgra_1931

0.702

Lgra_2916

0.683

mutT_1

0.594

polA

0.521

ogt

0.514

nth

0.497

ruvA

0.481

Your Current Organism:

Legionella gratiana

NCBI taxonomy Id: 45066
Other names: ATCC 49413, CCUG 44894, CIP 105267, DSM 21233, L. gratiana, NCTC 12388, strain Lyon 8420412

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lgra_1931	dnaN	Lgra_1931	Lgra_1281	Endonuclease/Exonuclease/phosphatase family protein.	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	0.738
Lgra_1931	mutY	Lgra_1931	Lgra_2915	Endonuclease/Exonuclease/phosphatase family protein.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.702
Lgra_1931	nth	Lgra_1931	Lgra_1076	Endonuclease/Exonuclease/phosphatase family protein.	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.735
Lgra_1931	polA	Lgra_1931	Lgra_1421	Endonuclease/Exonuclease/phosphatase family protein.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.664
Lgra_2916	mutY	Lgra_2916	Lgra_2915	Hypothetical protein.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.683
dnaN	Lgra_1931	Lgra_1281	Lgra_1931	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	Endonuclease/Exonuclease/phosphatase family protein.	0.738
dnaN	exoA	Lgra_1281	Lgra_2236	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	Exodeoxyribonuclease.	0.738
dnaN	mutY	Lgra_1281	Lgra_2915	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.861
dnaN	ogt	Lgra_1281	Lgra_2213	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	Ada protein (O6-methylguanine-DNA methyltransferase).	0.458
dnaN	polA	Lgra_1281	Lgra_1421	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.992
dnaN	xthA	Lgra_1281	Lgra_2237	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	Exodeoxyribonuclease III.	0.738
exoA	dnaN	Lgra_2236	Lgra_1281	Exodeoxyribonuclease.	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	0.738
exoA	mutY	Lgra_2236	Lgra_2915	Exodeoxyribonuclease.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.737
exoA	nth	Lgra_2236	Lgra_1076	Exodeoxyribonuclease.	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.975
exoA	polA	Lgra_2236	Lgra_1421	Exodeoxyribonuclease.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.664
exoA	xthA	Lgra_2236	Lgra_2237	Exodeoxyribonuclease.	Exodeoxyribonuclease III.	0.981
mutT_1	mutY	Lgra_0341	Lgra_2915	Mutator protein MutT; Belongs to the Nudix hydrolase family.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.594
mutY	Lgra_1931	Lgra_2915	Lgra_1931	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	Endonuclease/Exonuclease/phosphatase family protein.	0.702
mutY	Lgra_2916	Lgra_2915	Lgra_2916	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	Hypothetical protein.	0.683
mutY	dnaN	Lgra_2915	Lgra_1281	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	0.861