| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dnaG | rph | Lgra_2644 | Lgra_2969 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.775 |
| dnaG | rpsE | Lgra_2644 | Lgra_0386 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. | 0.422 |
| dnaG | rpsK | Lgra_2644 | Lgra_0391 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. | 0.448 |
| gmk | guaA | Lgra_2971 | Lgra_2459 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.972 |
| gmk | rph | Lgra_2971 | Lgra_2969 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.740 |
| gmk | tdcF | Lgra_2971 | Lgra_2974 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | L-PSP (mRNA) endoribonuclease. | 0.665 |
| gmk | yicC | Lgra_2971 | Lgra_2970 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Putative stress-induced protein. | 0.940 |
| guaA | gmk | Lgra_2459 | Lgra_2971 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.972 |
| guaA | rph | Lgra_2459 | Lgra_2969 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.757 |
| guaA | rpsD | Lgra_2459 | Lgra_0392 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.752 |
| guaA | rpsE | Lgra_2459 | Lgra_0386 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. | 0.779 |
| guaA | rpsK | Lgra_2459 | Lgra_0391 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. | 0.711 |
| guaA | tdcF | Lgra_2459 | Lgra_2974 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | L-PSP (mRNA) endoribonuclease. | 0.464 |
| guaA | yggV | Lgra_2459 | Lgra_0585 | GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.937 |
| lidP | rph | Lgra_1410 | Lgra_2969 | Exoribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.974 |
| lidP | rpsD | Lgra_1410 | Lgra_0392 | Exoribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.815 |
| lidP | rpsE | Lgra_1410 | Lgra_0386 | Exoribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. | 0.807 |
| lidP | rpsK | Lgra_1410 | Lgra_0391 | Exoribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. | 0.802 |
| rph | dnaG | Lgra_2969 | Lgra_2644 | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.775 |
| rph | gmk | Lgra_2969 | Lgra_2971 | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.740 |
