node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acnA | dlpA_2 | Llon_1213 | Llon_0706 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | 0.826 |
acnA | fumC | Llon_1213 | Llon_1990 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.658 |
acnA | icd | Llon_1213 | Llon_0594 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Isocitrate dehydrogenase. | 0.970 |
acnA | mdh | Llon_1213 | Llon_0047 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.557 |
acnA | prpC | Llon_1213 | Llon_0884 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 2-methylcitrate synthase; Belongs to the citrate synthase family. | 0.961 |
acnA | sdhA | Llon_1213 | Llon_0266 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.693 |
acnA | sucA | Llon_1213 | Llon_0264 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 2-oxoglutarate dehydrogenase E1. | 0.588 |
acnA | sucC | Llon_1213 | Llon_0262 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | Succinyl CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.764 |
acnA | sucD | Llon_1213 | Llon_0261 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.800 |
dlpA_2 | acnA | Llon_0706 | Llon_1213 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.826 |
dlpA_2 | icd | Llon_0706 | Llon_0594 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | Isocitrate dehydrogenase. | 0.945 |
dlpA_2 | mdh | Llon_0706 | Llon_0047 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. | 0.578 |
dlpA_2 | nuoI | Llon_0706 | Llon_1890 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | NADH dehydrogenase subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. | 0.654 |
dlpA_2 | prpC | Llon_0706 | Llon_0884 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | 2-methylcitrate synthase; Belongs to the citrate synthase family. | 0.618 |
dlpA_2 | sdhA | Llon_0706 | Llon_0266 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.771 |
dlpA_2 | sucA | Llon_0706 | Llon_0264 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | 2-oxoglutarate dehydrogenase E1. | 0.725 |
dlpA_2 | sucC | Llon_0706 | Llon_0262 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | Succinyl CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.591 |
dlpA_2 | sucD | Llon_0706 | Llon_0261 | DlpA protein (isocitrate and isopropylmalate dehydrogenase family protein). | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.616 |
fumC | acnA | Llon_1990 | Llon_1213 | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. | 0.658 |
fumC | icd | Llon_1990 | Llon_0594 | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Isocitrate dehydrogenase. | 0.781 |