STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa)    
Predicted Functional Partners:
pgl
6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
 
 0.999
edd
6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family.
 
 
 0.995
glk
Glucokinase; Belongs to the bacterial glucokinase family.
 
 
 0.981
eda
2-deydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase.
 
  
 0.954
pgi
Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 
 0.929
nagB
Glucosamine-6-phosphate deaminase 1; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
  
 
 0.893
gap
Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
 0.833
tkt
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 0.822
nadK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
   
 
 0.792
pdhB_1
Pyruvate/2-oxoglutarate dehydrogenase subunit E1.
   
 
 0.784
Your Current Organism:
Legionella parisiensis
NCBI taxonomy Id: 45071
Other names: ATCC 35299, CCUG 29670, CIP 103847, DSM 19216, JCM 7561, L. parisiensis, Legionella parisensis, NCTC 11983, strain PF-209C-C2
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