yyaP_1 protein (Legionella quateirensis) - STRING interaction network

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Score

yyaP_1

Dihydrofolate reductase. (182 aa)

Predicted Functional Partners:

thyA

0.966

ribD

0.838

gcvH

0.710

folC

0.709

gcvT

0.708

glyA

0.604

tmk

0.595

ygfZ

0.561

arnA

0.551

tdk

0.543

Your Current Organism:

Legionella quateirensis

NCBI taxonomy Id: 45072
Other names: ATCC 49507, CCUG 44899, CIP 105271, L. quateirensis, NCTC 12376

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
arnA	folC	Lqua_3024	Lqua_3115	Peptide synthetase, non-ribosomal.	Bifunctional protein FolC; Belongs to the folylpolyglutamate synthase family.	0.451
arnA	gcvH	Lqua_3024	Lqua_0756	Peptide synthetase, non-ribosomal.	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.706
arnA	gcvT	Lqua_3024	Lqua_0755	Peptide synthetase, non-ribosomal.	Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.	0.772
arnA	glyA	Lqua_3024	Lqua_1957	Peptide synthetase, non-ribosomal.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.806
arnA	ribD	Lqua_3024	Lqua_3239	Peptide synthetase, non-ribosomal.	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	0.405
arnA	thyA	Lqua_3024	Lqua_1728	Peptide synthetase, non-ribosomal.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.718
arnA	tmk	Lqua_3024	Lqua_0975	Peptide synthetase, non-ribosomal.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.466
arnA	yyaP_1	Lqua_3024	Lqua_2830	Peptide synthetase, non-ribosomal.	Dihydrofolate reductase.	0.551
folC	arnA	Lqua_3115	Lqua_3024	Bifunctional protein FolC; Belongs to the folylpolyglutamate synthase family.	Peptide synthetase, non-ribosomal.	0.451
folC	gcvT	Lqua_3115	Lqua_0755	Bifunctional protein FolC; Belongs to the folylpolyglutamate synthase family.	Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.	0.685
folC	glyA	Lqua_3115	Lqua_1957	Bifunctional protein FolC; Belongs to the folylpolyglutamate synthase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.832
folC	ribD	Lqua_3115	Lqua_3239	Bifunctional protein FolC; Belongs to the folylpolyglutamate synthase family.	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	0.849
folC	thyA	Lqua_3115	Lqua_1728	Bifunctional protein FolC; Belongs to the folylpolyglutamate synthase family.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.786
folC	yyaP_1	Lqua_3115	Lqua_2830	Bifunctional protein FolC; Belongs to the folylpolyglutamate synthase family.	Dihydrofolate reductase.	0.709
gcvH	arnA	Lqua_0756	Lqua_3024	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Peptide synthetase, non-ribosomal.	0.706
gcvH	gcvT	Lqua_0756	Lqua_0755	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.	0.999
gcvH	glyA	Lqua_0756	Lqua_1957	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.959
gcvH	thyA	Lqua_0756	Lqua_1728	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.778
gcvH	ygfZ	Lqua_0756	Lqua_1215	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine cleavage T protein.	0.744
gcvH	yyaP_1	Lqua_0756	Lqua_2830	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Dihydrofolate reductase.	0.710