STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Lsan_2000Putative CoA-dependent acyltransferase. (706 aa)    
Predicted Functional Partners:
Lsan_1609
Pyruvate/2-oxoglutarate dehydrogenase subunit E1.
  
 0.993
odpB
Pyruvate dehydrogenase E1 subunit beta.
  
 0.961
lpdA
Dihydrolipoyl dehydrogenase.
   
 0.933
sucA
2-oxoglutarate dehydrogenase E1.
  
 0.899
Lsan_1052
acyl-CoA synthetase.
  
 0.878
aceE
Pyruvate dehydrogenase (decarboxylase component) E1p; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.863
succ
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.820
sucD
succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.793
merA1
Mercuric reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
   
 0.780
Lsan_0983
Oxydoreductase.
   
 0.780
Your Current Organism:
Legionella santicrucis
NCBI taxonomy Id: 45074
Other names: ATCC 35301, CCUG 29673, CIP 103849, DSM 23075, JCM 7557, L. santicrucis, Legionella sancticrucis, Legionella santacruxensis, NCTC 11989, strain SC-63-C7
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.