Lwor_0919 protein (Legionella worsleiensis) - STRING interaction network

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Score

Lwor_0919

S-adenosyl-L-homocysteine hydrolase. (377 aa)

Predicted Functional Partners:

metK

0.851

tuf

0.729

cysK

0.581

pnp

0.545

ydfJ

0.540

metC

0.531

Lwor_0888

0.520

glyA

0.515

lysAC_1

0.468

metG

0.461

Your Current Organism:

Legionella worsleiensis

NCBI taxonomy Id: 45076
Other names: ATCC 49508, CCUG 44923, CIP 105114, DSM 21907, L. worsleiensis, NCTC 12377

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lwor_0888	Lwor_0919	Lwor_0888	Lwor_0919	Hypothetical protein.	S-adenosyl-L-homocysteine hydrolase.	0.520
Lwor_0888	glyA	Lwor_0888	Lwor_0060	Hypothetical protein.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.596
Lwor_0888	metK	Lwor_0888	Lwor_0799	Hypothetical protein.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.413
Lwor_0919	Lwor_0888	Lwor_0919	Lwor_0888	S-adenosyl-L-homocysteine hydrolase.	Hypothetical protein.	0.520
Lwor_0919	cysK	Lwor_0919	Lwor_1246	S-adenosyl-L-homocysteine hydrolase.	Cystathionine beta synthase.	0.581
Lwor_0919	glyA	Lwor_0919	Lwor_0060	S-adenosyl-L-homocysteine hydrolase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.515
Lwor_0919	lysAC_1	Lwor_0919	Lwor_0900	S-adenosyl-L-homocysteine hydrolase.	Bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.468
Lwor_0919	metC	Lwor_0919	Lwor_2576	S-adenosyl-L-homocysteine hydrolase.	Cystathionine beta-lyase.	0.531
Lwor_0919	metG	Lwor_0919	Lwor_1311	S-adenosyl-L-homocysteine hydrolase.	Methionyl tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.461
Lwor_0919	metK	Lwor_0919	Lwor_0799	S-adenosyl-L-homocysteine hydrolase.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.851
Lwor_0919	pnp	Lwor_0919	Lwor_1421	S-adenosyl-L-homocysteine hydrolase.	Polynucleotide phosphorylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.	0.545
Lwor_0919	tuf	Lwor_0919	Lwor_1436	S-adenosyl-L-homocysteine hydrolase.	Elongation factor Tu (EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.729
Lwor_0919	ydfJ	Lwor_0919	Lwor_0920	S-adenosyl-L-homocysteine hydrolase.	Membrane protein YdfJ.	0.540
cysK	Lwor_0919	Lwor_1246	Lwor_0919	Cystathionine beta synthase.	S-adenosyl-L-homocysteine hydrolase.	0.581
cysK	glyA	Lwor_1246	Lwor_0060	Cystathionine beta synthase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.735
cysK	lysAC_1	Lwor_1246	Lwor_0900	Cystathionine beta synthase.	Bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.789
cysK	metC	Lwor_1246	Lwor_2576	Cystathionine beta synthase.	Cystathionine beta-lyase.	0.994
cysK	metG	Lwor_1246	Lwor_1311	Cystathionine beta synthase.	Methionyl tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.	0.473
glyA	Lwor_0888	Lwor_0060	Lwor_0888	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Hypothetical protein.	0.596
glyA	Lwor_0919	Lwor_0060	Lwor_0919	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	S-adenosyl-L-homocysteine hydrolase.	0.515