pieE_1 protein (Legionella worsleiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

pieE_1

Substrate of the Dot/Icm secretion system. (611 aa)

Predicted Functional Partners:

rpsN

0.868

dksA

0.801

map_2

0.772

rpmB

0.737

rpmG

0.550

rpmE

0.427

Your Current Organism:

Legionella worsleiensis

NCBI taxonomy Id: 45076
Other names: ATCC 49508, CCUG 44923, CIP 105114, DSM 21907, L. worsleiensis, NCTC 12377

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
dksA	pieE_1	Lwor_0995	Lwor_1270	DnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.	Substrate of the Dot/Icm secretion system.	0.801
map_2	pieE_1	Lwor_2235	Lwor_1270	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	Substrate of the Dot/Icm secretion system.	0.772
map_2	rpmB	Lwor_2235	Lwor_1062	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	0.485
map_2	rpmG	Lwor_2235	Lwor_1061	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.	0.510
map_2	rpsN	Lwor_2235	Lwor_1451	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	30S ribosomal protein S14.	0.991
pieE_1	dksA	Lwor_1270	Lwor_0995	Substrate of the Dot/Icm secretion system.	DnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.	0.801
pieE_1	map_2	Lwor_1270	Lwor_2235	Substrate of the Dot/Icm secretion system.	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	0.772
pieE_1	rpmB	Lwor_1270	Lwor_1062	Substrate of the Dot/Icm secretion system.	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	0.737
pieE_1	rpmE	Lwor_1270	Lwor_2385	Substrate of the Dot/Icm secretion system.	50S ribosomal protein L31; Binds the 23S rRNA.	0.427
pieE_1	rpmG	Lwor_1270	Lwor_1061	Substrate of the Dot/Icm secretion system.	50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.	0.550
pieE_1	rpsN	Lwor_1270	Lwor_1451	Substrate of the Dot/Icm secretion system.	30S ribosomal protein S14.	0.868
rpmB	map_2	Lwor_1062	Lwor_2235	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	0.485
rpmB	pieE_1	Lwor_1062	Lwor_1270	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	Substrate of the Dot/Icm secretion system.	0.737
rpmB	rpmE	Lwor_1062	Lwor_2385	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	50S ribosomal protein L31; Binds the 23S rRNA.	0.997
rpmB	rpmG	Lwor_1062	Lwor_1061	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.	0.999
rpmB	rpsN	Lwor_1062	Lwor_1451	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	30S ribosomal protein S14.	0.998
rpmE	pieE_1	Lwor_2385	Lwor_1270	50S ribosomal protein L31; Binds the 23S rRNA.	Substrate of the Dot/Icm secretion system.	0.427
rpmE	rpmB	Lwor_2385	Lwor_1062	50S ribosomal protein L31; Binds the 23S rRNA.	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	0.997
rpmE	rpmG	Lwor_2385	Lwor_1061	50S ribosomal protein L31; Binds the 23S rRNA.	50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.	0.997
rpmE	rpsN	Lwor_2385	Lwor_1451	50S ribosomal protein L31; Binds the 23S rRNA.	30S ribosomal protein S14.	0.981