typA protein (Legionella worsleiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

typA

Virulence regulator BipA. (608 aa)

Predicted Functional Partners:

engA

0.902

guaA

0.897

rplA

0.871

recN

0.850

rpsI

0.831

tsf

0.821

rpoB

0.820

rplD

0.817

ppnK

0.807

rpsJ

0.805

Your Current Organism:

Legionella worsleiensis

NCBI taxonomy Id: 45076
Other names: ATCC 49508, CCUG 44923, CIP 105114, DSM 21907, L. worsleiensis, NCTC 12377

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
engA	guaA	Lwor_0672	Lwor_2239	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.493
engA	recN	Lwor_0672	Lwor_1366	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	DNA repair protein recN; May be involved in recombinational repair of damaged DNA.	0.465
engA	rplA	Lwor_0672	Lwor_1593	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.590
engA	tsf	Lwor_0672	Lwor_2230	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	Translation elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.441
engA	typA	Lwor_0672	Lwor_1368	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	Virulence regulator BipA.	0.902
guaA	engA	Lwor_2239	Lwor_0672	GMP synthase; Catalyzes the synthesis of GMP from XMP.	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	0.493
guaA	rplA	Lwor_2239	Lwor_1593	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	0.950
guaA	rplD	Lwor_2239	Lwor_1439	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L4; Forms part of the polypeptide exit tunnel.	0.778
guaA	rpoB	Lwor_2239	Lwor_1590	GMP synthase; Catalyzes the synthesis of GMP from XMP.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.943
guaA	rpsI	Lwor_2239	Lwor_1494	GMP synthase; Catalyzes the synthesis of GMP from XMP.	30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.	0.538
guaA	rpsJ	Lwor_2239	Lwor_1437	GMP synthase; Catalyzes the synthesis of GMP from XMP.	30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.735
guaA	tsf	Lwor_2239	Lwor_2230	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Translation elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.871
guaA	typA	Lwor_2239	Lwor_1368	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Virulence regulator BipA.	0.897
ppnK	recN	Lwor_1367	Lwor_1366	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	DNA repair protein recN; May be involved in recombinational repair of damaged DNA.	0.853
ppnK	typA	Lwor_1367	Lwor_1368	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Virulence regulator BipA.	0.807
recN	engA	Lwor_1366	Lwor_0672	DNA repair protein recN; May be involved in recombinational repair of damaged DNA.	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	0.465
recN	ppnK	Lwor_1366	Lwor_1367	DNA repair protein recN; May be involved in recombinational repair of damaged DNA.	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.853
recN	typA	Lwor_1366	Lwor_1368	DNA repair protein recN; May be involved in recombinational repair of damaged DNA.	Virulence regulator BipA.	0.850
rplA	engA	Lwor_1593	Lwor_0672	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	0.590
rplA	guaA	Lwor_1593	Lwor_2239	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.950