trpE protein (Legionella worsleiensis) - STRING interaction network

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Score

trpE

Anthranilate synthase. (715 aa)

Predicted Functional Partners:

trpC

0.999

trpD

0.999

pabB

0.993

trpG

0.993

trpF

0.987

trpB

0.977

trpA

0.977

folP

0.956

folK

0.907

aroC

0.887

Your Current Organism:

Legionella worsleiensis

NCBI taxonomy Id: 45076
Other names: ATCC 49508, CCUG 44923, CIP 105114, DSM 21907, L. worsleiensis, NCTC 12377

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aroC	pabB	Lwor_0964	Lwor_0694	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Para-aminobenzoate synthase, component I.	0.859
aroC	trpA	Lwor_0964	Lwor_0319	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.908
aroC	trpB	Lwor_0964	Lwor_0318	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.672
aroC	trpC	Lwor_0964	Lwor_2524	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.	0.763
aroC	trpD	Lwor_0964	Lwor_2525	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).	0.836
aroC	trpE	Lwor_0964	Lwor_2252	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Anthranilate synthase.	0.887
aroC	trpF	Lwor_0964	Lwor_0317	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family.	0.722
aroC	trpG	Lwor_0964	Lwor_2526	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	Anthranilate synthase component II.	0.799
folK	folP	Lwor_0664	Lwor_1396	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	0.997
folK	pabB	Lwor_0664	Lwor_0694	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Para-aminobenzoate synthase, component I.	0.659
folK	trpE	Lwor_0664	Lwor_2252	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Anthranilate synthase.	0.907
folK	trpG	Lwor_0664	Lwor_2526	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	Anthranilate synthase component II.	0.424
folP	folK	Lwor_1396	Lwor_0664	7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	0.997
folP	pabB	Lwor_1396	Lwor_0694	7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	Para-aminobenzoate synthase, component I.	0.700
folP	trpE	Lwor_1396	Lwor_2252	7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	Anthranilate synthase.	0.956
folP	trpG	Lwor_1396	Lwor_2526	7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	Anthranilate synthase component II.	0.612
pabB	aroC	Lwor_0694	Lwor_0964	Para-aminobenzoate synthase, component I.	Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.	0.859
pabB	folK	Lwor_0694	Lwor_0664	Para-aminobenzoate synthase, component I.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.	0.659
pabB	folP	Lwor_0694	Lwor_1396	Para-aminobenzoate synthase, component I.	7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	0.700
pabB	trpA	Lwor_0694	Lwor_0319	Para-aminobenzoate synthase, component I.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.977