STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHZ_c0405Threonine dehydratase. (329 aa)    
Predicted Functional Partners:
ilvN
Acetolactate synthase, small subunit.
  
 
 0.838
PHZ_c0406
Glyoxalase/bleomycin resistance protein/dioxygenase.
       0.777
PHZ_c0567
Hiamine-pyrophosphate-requiring enzyme.
  
 0.686
ilvI
Acetolactate synthase, large subunit.
  
 0.686
ilvC
Ketol-acid reductoisomerase protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
 0.672
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
  
 0.666
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
     
 0.633
pabB
Para-aminobenzoate synthase, component I.
  
  
 0.611
gltB
Glutamate synthase, large subunit.
  
 
 0.607
PHZ_c2074
Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
  
 0.591
Your Current Organism:
Phenylobacterium zucineum
NCBI taxonomy Id: 450851
Other names: P. zucineum HLK1, Phenylobacterium zucineum HLK1, Phenylobacterium zucineum str. HLK1, Phenylobacterium zucineum strain HLK1
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