PHZ_c1109 protein (Phenylobacterium zucineum)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

PHZ_c1109

Conserved hypothetical protein. (359 aa)

Predicted Functional Partners:

PHZ_c0375

0.759

PHZ_c1666

0.754

PHZ_c2173

0.602

fadB

0.570

moaA

0.566

PHZ_c1132

0.559

PHZ_c1263

0.557

betA

0.543

PHZ_c3098

0.543

PHZ_c3418

0.531

Your Current Organism:

Phenylobacterium zucineum

NCBI taxonomy Id: 450851
Other names: P. zucineum HLK1, Phenylobacterium zucineum HLK1, Phenylobacterium zucineum str. HLK1, Phenylobacterium zucineum strain HLK1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHZ_c0375	PHZ_c1109	PHZ_c0375	PHZ_c1109	TonB-dependent receptor.	Conserved hypothetical protein.	0.759
PHZ_c0375	PHZ_c1132	PHZ_c0375	PHZ_c1132	TonB-dependent receptor.	TonB-dependent receptor for transport vitamin B12.	0.559
PHZ_c0375	PHZ_c1666	PHZ_c0375	PHZ_c1666	TonB-dependent receptor.	Conserved hypothetical protein.	0.732
PHZ_c1109	PHZ_c0375	PHZ_c1109	PHZ_c0375	Conserved hypothetical protein.	TonB-dependent receptor.	0.759
PHZ_c1109	PHZ_c1132	PHZ_c1109	PHZ_c1132	Conserved hypothetical protein.	TonB-dependent receptor for transport vitamin B12.	0.559
PHZ_c1109	PHZ_c1263	PHZ_c1109	PHZ_c1263	Conserved hypothetical protein.	Conserved hypothetical protein.	0.557
PHZ_c1109	PHZ_c1666	PHZ_c1109	PHZ_c1666	Conserved hypothetical protein.	Conserved hypothetical protein.	0.754
PHZ_c1109	PHZ_c2173	PHZ_c1109	PHZ_c2173	Conserved hypothetical protein.	TonB-dependent receptor.	0.602
PHZ_c1109	PHZ_c3098	PHZ_c1109	PHZ_c3098	Conserved hypothetical protein.	Autotransporter.	0.543
PHZ_c1109	PHZ_c3418	PHZ_c1109	PHZ_c3418	Conserved hypothetical protein.	NADP-dependent malic enzyme.	0.531
PHZ_c1109	betA	PHZ_c1109	PHZ_c1110	Conserved hypothetical protein.	Choline dehydrogenase.	0.543
PHZ_c1109	fadB	PHZ_c1109	PHZ_c1108	Conserved hypothetical protein.	Enoyl CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.570
PHZ_c1109	moaA	PHZ_c1109	PHZ_c0280	Conserved hypothetical protein.	Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.	0.566
PHZ_c1132	PHZ_c0375	PHZ_c1132	PHZ_c0375	TonB-dependent receptor for transport vitamin B12.	TonB-dependent receptor.	0.559
PHZ_c1132	PHZ_c1109	PHZ_c1132	PHZ_c1109	TonB-dependent receptor for transport vitamin B12.	Conserved hypothetical protein.	0.559
PHZ_c1132	PHZ_c1666	PHZ_c1132	PHZ_c1666	TonB-dependent receptor for transport vitamin B12.	Conserved hypothetical protein.	0.756
PHZ_c1132	PHZ_c2173	PHZ_c1132	PHZ_c2173	TonB-dependent receptor for transport vitamin B12.	TonB-dependent receptor.	0.488
PHZ_c1132	PHZ_c3098	PHZ_c1132	PHZ_c3098	TonB-dependent receptor for transport vitamin B12.	Autotransporter.	0.421
PHZ_c1263	PHZ_c1109	PHZ_c1263	PHZ_c1109	Conserved hypothetical protein.	Conserved hypothetical protein.	0.557
PHZ_c1666	PHZ_c0375	PHZ_c1666	PHZ_c0375	Conserved hypothetical protein.	TonB-dependent receptor.	0.732

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.828

expected number of edges:

12

PPI enrichment p-value:

0.00232

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032088

Negative regulation of NF-kappaB transcription factor activity

3 of 47

2.12

1.01

0.0130

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8873

COMM domain, and The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

10 of 19

3.04

12.98

1.02e-25

CL:8878

COMM domain

8 of 10

3.22

10.99

3.24e-21

CL:8685

Neddylation, and Ankyrin repeat domain-containing protein AN34A/B/C

11 of 146

2.19

8.13

1.12e-21

CL:8882

COMM domain

3 of 5

3.1

3.05

2.89e-06

CL:8901

Mixed, incl. BRCA1-BARD1 complex, and Dendritic cell migration

2 of 5

2.92

1.45

0.0024

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

11 of 406

1.75

4.62

1.08e-16

MAP-597592

Post-translational protein modification

11 of 2250

1.01

1.25

7.18e-09

MAP-392499

Metabolism of proteins

11 of 2844

0.91

1.02

6.26e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07258

COMM domain

8 of 10

3.22

10.77

8.85e-21

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017920

COMM domain

8 of 10

3.22

10.51

2.76e-20

IPR047155

COMM domain-containing protein 4/6/7/8

4 of 4

3.32

4.49

7.19e-09

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