STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHZ_c27955-aminolevulinic acid synthase. (409 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.913
PHZ_c2109
Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.913
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.913
gcvP
Glycine cleavage system P protein, subunit 2.
  
 
 0.911
hemB
Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
    
 0.911
gcvPA
Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
  
 
 0.910
PHZ_c0751
Threonine aldolase.
    
 0.908
PHZ_c2374
FAD dependent oxidoreductase.
    
 0.904
hemA
5-aminolevulinic acid synthase.
  
  
 
0.900
fabD
Malonyl CoA-acyl carrier protein transacylase.
 
 
 0.859
Your Current Organism:
Phenylobacterium zucineum
NCBI taxonomy Id: 450851
Other names: P. zucineum HLK1, Phenylobacterium zucineum HLK1, Phenylobacterium zucineum str. HLK1, Phenylobacterium zucineum strain HLK1
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