Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
A0A0N5API8DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (696 aa)    
Predicted Functional Partners:
A0A0N5AX62
Uncharacterized protein.
    
 
 0.979
A0A0N5AKI0
Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
    
 
 0.968
A0A0N5A7J8
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.967
A0A0N5A8U1
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
    
 
 0.963
A0A0N5ASK4
ERCC4 domain-containing protein.
    
 
 0.963
A0A0N5AL92
Uncharacterized protein.
   
 
 0.961
A0A0N5ATF3
Uncharacterized protein.
   
 
 0.952
A0A0N5ATW9
Uncharacterized protein.
   
   0.949
A0A0N5A9V8
Uncharacterized protein.
   
 
 0.947
A0A0N5ADR2
Ubiquitin-like domain-containing protein.
   
 0.935
Your Current Organism:
Syphacia muris
NCBI taxonomy Id: 451379
Other names: S. muris
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