Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Lspi_06572-oxoisovalerate dehydrogenase, E1 component, alpha and beta fusion. (745 aa)    
Predicted Functional Partners:
Lspi_2226
Branched-chain alpha-keto acid dehydrogenase subunit E2.
 
 0.999
Lspi_2300
Dihydrolipoamide dehydrogenase.
 
 0.994
odpB_1
Pyruvate dehydrogenase E1 subunit beta.
 
0.990
pdhA
Pyruvate dehydrogenase e1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 
0.990
sucB_2
Dihydrolipoamide succinyltransferase subunit E2.
 
 0.990
sucB_1
Dihydrolipoamide succinyltransferase subunit E2; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
 0.988
Lspi_2299
Pyruvate dehydrogenase E2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.988
Lspi_0714
Putative CoA-dependent acyltransferase.
  
 0.986
Lspi_1907
Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
 
 
 0.985
gor
Glutathione reductase.
 
 0.945
Your Current Organism:
Legionella spiritensis
NCBI taxonomy Id: 452
Other names: ATCC 35249, CCUG 29715, CCUG 31118, CIP 103850, DSM 19324, JCM 7562, L. spiritensis, NCTC 11990, strain Mount Saint Helens 9
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