| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lspi_2254 | glyA | Lspi_2254 | Lspi_2610 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.963 |
| Lspi_2254 | pssA | Lspi_2254 | Lspi_0322 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | CDP-diacylglycerol-serine O-phosphatidyltransferase (phosphatidylserine synthase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| Lspi_2254 | trpA | Lspi_2254 | Lspi_2281 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.912 |
| Lspi_2254 | trpB | Lspi_2254 | Lspi_2280 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| glyA | Lspi_2254 | Lspi_2610 | Lspi_2254 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.963 |
| glyA | pssA | Lspi_2610 | Lspi_0322 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol-serine O-phosphatidyltransferase (phosphatidylserine synthase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| glyA | trpA | Lspi_2610 | Lspi_2281 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.926 |
| glyA | trpB | Lspi_2610 | Lspi_2280 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.919 |
| glyA | trpE_1 | Lspi_2610 | Lspi_0968 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Anthranilate synthase. | 0.575 |
| pabB | trpA | Lspi_2229 | Lspi_2281 | Para-aminobenzoate synthase, component I. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.964 |
| pabB | trpB | Lspi_2229 | Lspi_2280 | Para-aminobenzoate synthase, component I. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.970 |
| pabB | trpC | Lspi_2229 | Lspi_0240 | Para-aminobenzoate synthase, component I. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.995 |
| pabB | trpD | Lspi_2229 | Lspi_0241 | Para-aminobenzoate synthase, component I. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.992 |
| pabB | trpE_1 | Lspi_2229 | Lspi_0968 | Para-aminobenzoate synthase, component I. | Anthranilate synthase. | 0.983 |
| pabB | trpF | Lspi_2229 | Lspi_2279 | Para-aminobenzoate synthase, component I. | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. | 0.946 |
| pabB | trpG | Lspi_2229 | Lspi_0242 | Para-aminobenzoate synthase, component I. | Anthranilate synthase component II. | 0.999 |
| pssA | Lspi_2254 | Lspi_0322 | Lspi_2254 | CDP-diacylglycerol-serine O-phosphatidyltransferase (phosphatidylserine synthase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.900 |
| pssA | glyA | Lspi_0322 | Lspi_2610 | CDP-diacylglycerol-serine O-phosphatidyltransferase (phosphatidylserine synthase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
| pssA | trpA | Lspi_0322 | Lspi_2281 | CDP-diacylglycerol-serine O-phosphatidyltransferase (phosphatidylserine synthase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
| pssA | trpB | Lspi_0322 | Lspi_2280 | CDP-diacylglycerol-serine O-phosphatidyltransferase (phosphatidylserine synthase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
