Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KQK27085.1Clp protease ClpC; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family. (843 aa)    
Predicted Functional Partners:
clpP
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
 
 0.884
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.875
KQK25820.1
Clp protease ClpS; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpS family.
  
 
 0.720
KQK26646.1
Molecular chaperone Hsp90; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.716
grpE
Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]
 
 
 0.708
lon
Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
  
 
 0.559
KQK25474.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 
 0.545
KQK27084.1
Glycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.520
KQK27451.1
Uroporphyrinogen decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.520
KQK25991.1
Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.511
Your Current Organism:
Chryseobacterium aquaticum
NCBI taxonomy Id: 452084
Other names: C. aquaticum, CECT 7302, Chryseobacterium aquaticum Kim et al. 2008 emend. Hahnke et al. 2016, Chryseobacterium sp. 10-106, Chryseobacterium sp. 10-46, Chryseobacterium sp. VR86, KCTC 12483, strain 10-46
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