TCAP_03663 protein (Tolypocladium capitatum)

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TCAP_03663

Uncharacterized protein. (860 aa)

Predicted Functional Partners:

TCAP_03178

0.993

TCAP_01281

0.993

TCAP_04429

0.992

TCAP_04125

0.988

TCAP_03414

0.985

TCAP_06452

0.970

TCAP_05098

0.959

TCAP_01958

0.959

TCAP_02397

0.931

TCAP_05520

0.901

Your Current Organism:

Tolypocladium capitatum

NCBI taxonomy Id: 45235
Other names: Clavaria capitata, Cordyceps capitata, Elaphocordyceps capitata, T. capitatum, Tolypocladium capitatum (Holmsk. : Fr.) Quandt, Kepler & Spatafora, 2014, Torrubia capitata

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TCAP_01281	TCAP_01958	A0A2K3QMP9	A0A2K3QKP8	Uncharacterized protein.	Actin-like protein; Belongs to the actin family.	0.926
TCAP_01281	TCAP_02397	A0A2K3QMP9	A0A2K3QJH3	Uncharacterized protein.	Cytoplasmic dynein 1 intermediate chain 2.	0.885
TCAP_01281	TCAP_03178	A0A2K3QMP9	A0A2K3QHB1	Uncharacterized protein.	Dynactin subunit 2.	0.991
TCAP_01281	TCAP_03414	A0A2K3QMP9	A0A2K3QGF7	Uncharacterized protein.	Dynactin.	0.983
TCAP_01281	TCAP_03663	A0A2K3QMP9	A0A2K3QFT0	Uncharacterized protein.	Uncharacterized protein.	0.993
TCAP_01281	TCAP_04125	A0A2K3QMP9	A0A2K3QEH2	Uncharacterized protein.	Dynactin subunit 5.	0.998
TCAP_01281	TCAP_04429	A0A2K3QMP9	A0A2K3QDL7	Uncharacterized protein.	Dynactin subunit 4.	0.998
TCAP_01281	TCAP_05098	A0A2K3QMP9	A0A2K3QBQ2	Uncharacterized protein.	Actin.	0.926
TCAP_01281	TCAP_05520	A0A2K3QMP9	A0A2K3QAH3	Uncharacterized protein.	Actin-like protein 4; Belongs to the actin family.	0.782
TCAP_01281	TCAP_06452	A0A2K3QMP9	A0A2K3Q7W7	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.967
TCAP_01958	TCAP_01281	A0A2K3QKP8	A0A2K3QMP9	Actin-like protein; Belongs to the actin family.	Uncharacterized protein.	0.926
TCAP_01958	TCAP_02397	A0A2K3QKP8	A0A2K3QJH3	Actin-like protein; Belongs to the actin family.	Cytoplasmic dynein 1 intermediate chain 2.	0.837
TCAP_01958	TCAP_03178	A0A2K3QKP8	A0A2K3QHB1	Actin-like protein; Belongs to the actin family.	Dynactin subunit 2.	0.969
TCAP_01958	TCAP_03414	A0A2K3QKP8	A0A2K3QGF7	Actin-like protein; Belongs to the actin family.	Dynactin.	0.936
TCAP_01958	TCAP_03663	A0A2K3QKP8	A0A2K3QFT0	Actin-like protein; Belongs to the actin family.	Uncharacterized protein.	0.959
TCAP_01958	TCAP_04125	A0A2K3QKP8	A0A2K3QEH2	Actin-like protein; Belongs to the actin family.	Dynactin subunit 5.	0.918
TCAP_01958	TCAP_04429	A0A2K3QKP8	A0A2K3QDL7	Actin-like protein; Belongs to the actin family.	Dynactin subunit 4.	0.947
TCAP_01958	TCAP_05520	A0A2K3QKP8	A0A2K3QAH3	Actin-like protein; Belongs to the actin family.	Actin-like protein 4; Belongs to the actin family.	0.963
TCAP_01958	TCAP_06452	A0A2K3QKP8	A0A2K3Q7W7	Actin-like protein; Belongs to the actin family.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.942
TCAP_02397	TCAP_01281	A0A2K3QJH3	A0A2K3QMP9	Cytoplasmic dynein 1 intermediate chain 2.	Uncharacterized protein.	0.885

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.915

expected number of edges:

19

PPI enrichment p-value:

1.05e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098662

Inorganic cation transmembrane transport

10 of 176

1.78

4.33

3.20e-14

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

3 of 3

3.02

3.29

1.01e-06

GO:0006810

Transport

11 of 1358

0.93

1.1

6.24e-09

GO:0030003

Cellular cation homeostasis

3 of 97

1.51

1.03

0.0053

GO:0098771

Inorganic ion homeostasis

3 of 109

1.46

0.97

0.0068

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

7 of 12

2.79

7.44

4.47e-15

GO:0015078

Proton transmembrane transporter activity

8 of 86

1.99

4.87

4.78e-13

GO:0019829

ATPase-coupled cation transmembrane transporter activity

7 of 63

2.07

4.69

1.05e-11

GO:0022890

Inorganic cation transmembrane transporter activity

10 of 193

1.74

4.23

1.18e-14

GO:0009678

Pyrophosphate hydrolysis-driven proton transmembrane transporter activity

5 of 44

2.08

3.45

3.56e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033178

Proton-transporting two-sector ATPase complex, catalytic domain

6 of 17

2.57

5.58

1.11e-11

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

6 of 17

2.57

5.58

1.11e-11

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

5 of 8

2.82

5.45

5.51e-11

GO:0016469

Proton-transporting two-sector ATPase complex

7 of 55

2.13

4.82

1.11e-11

GO:0005754

Mitochondrial proton-transporting ATP synthase, catalytic core

4 of 5

2.93

4.43

6.39e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8347

Proton-transporting ATP synthase complex

6 of 14

2.65

5.72

8.65e-12

CL:8333

Proton-transporting two-sector ATPase complex

7 of 59

2.1

4.63

2.47e-11

CL:8352

Proton channel activity

3 of 5

2.8

2.76

8.32e-06

CL:13508

Copper ion transport

2 of 6

2.55

1.3

0.0042

CL:13238

Mixed, incl. Cation homeostasis, and Lipid transport

4 of 174

1.38

1.04

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 143

1.77

3.77

1.58e-11

map04016

MAPK signaling pathway - plant

2 of 7

2.48

1.45

0.0021

map01100

Metabolic pathways

8 of 2025

0.62

0.46

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-936837

Ion transport by P-type ATPases

3 of 29

2.04

1.31

0.0030

MAP-983712

Ion channel transport

3 of 62

1.71

0.94

0.0128

MAP-1852241

Organelle biogenesis and maintenance

3 of 68

1.67

0.93

0.0128

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

3 of 75

1.62

0.92

0.0128

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

6 of 13

2.69

5.93

3.63e-12

GOCC:0016020

Membrane

11 of 1420

0.91

1.05

1.91e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0139

CF(1)

5 of 6

2.94

5.66

2.89e-11

KW-0066

ATP synthesis

5 of 6

2.94

5.66

2.89e-11

KW-0375

Hydrogen ion transport

3 of 22

2.16

2.12

6.86e-05

KW-0067

ATP-binding

8 of 418

1.3

1.88

3.68e-08

KW-1278

Translocase

2 of 26

1.91

1.02

0.0104

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02874

ATP synthase alpha/beta family, beta-barrel domain

5 of 7

2.88

5.14

2.50e-10

PF00122

E1-E2 ATPase

4 of 28

2.18

2.53

9.30e-06

PF00702

Haloacid dehalogenase-like hydrolase

3 of 14

2.35

1.99

0.00017

PF00006

ATP synthase alpha/beta family, nucleotide-binding domain

2 of 4

2.72

1.34

0.0037

PF00403

Heavy-metal-associated domain

2 of 6

2.55

1.24

0.0055

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036121

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily

5 of 6

2.94

5.06

4.16e-10

IPR020003

ATPase, alpha/beta subunit, nucleotide-binding domain, active site

5 of 7

2.88

5.03

4.16e-10

IPR004100

ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain

5 of 7

2.88

5.03

4.16e-10

IPR000194

ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain

5 of 7

2.88

5.03

4.16e-10

IPR005722

ATP synthase, F1 complex, beta subunit

3 of 3

3.02

2.78

8.67e-06

(more ...)

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