node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | TCAP_01678 | A0A2K3QBE9 | A0A2K3QLH6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 4. | 0.875 |
FEN1 | TCAP_01922 | A0A2K3QBE9 | A0A2K3QKV3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.967 |
FEN1 | TCAP_02414 | A0A2K3QBE9 | A0A2K3QJG9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 3. | 0.857 |
FEN1 | TCAP_03073 | A0A2K3QBE9 | A0A2K3QHI1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 5. | 0.914 |
FEN1 | TCAP_04122 | A0A2K3QBE9 | A0A2K3QEI0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase. | 0.970 |
FEN1 | TCAP_04398 | A0A2K3QBE9 | A0A2K3QDQ7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase delta small subunit. | 0.911 |
FEN1 | TCAP_05365 | A0A2K3QBE9 | A0A2K3QAX9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.931 |
FEN1 | TCAP_05609 | A0A2K3QBE9 | A0A2K3QA49 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | N-acetyltransferase eso1. | 0.773 |
FEN1 | TCAP_06435 | A0A2K3QBE9 | A0A2K3Q7P4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication factor C subunit 2. | 0.895 |
FEN1 | TCAP_06965 | A0A2K3QBE9 | A0A2K3Q689 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.846 |
TCAP_01678 | FEN1 | A0A2K3QLH6 | A0A2K3QBE9 | Replication factor C subunit 4. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.875 |
TCAP_01678 | TCAP_01922 | A0A2K3QLH6 | A0A2K3QKV3 | Replication factor C subunit 4. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.976 |
TCAP_01678 | TCAP_02414 | A0A2K3QLH6 | A0A2K3QJG9 | Replication factor C subunit 4. | Replication factor C subunit 3. | 0.999 |
TCAP_01678 | TCAP_03073 | A0A2K3QLH6 | A0A2K3QHI1 | Replication factor C subunit 4. | Replication factor C subunit 5. | 0.999 |
TCAP_01678 | TCAP_04122 | A0A2K3QLH6 | A0A2K3QEI0 | Replication factor C subunit 4. | DNA polymerase. | 0.850 |
TCAP_01678 | TCAP_04398 | A0A2K3QLH6 | A0A2K3QDQ7 | Replication factor C subunit 4. | DNA polymerase delta small subunit. | 0.804 |
TCAP_01678 | TCAP_05365 | A0A2K3QLH6 | A0A2K3QAX9 | Replication factor C subunit 4. | DNA ligase. | 0.780 |
TCAP_01678 | TCAP_05609 | A0A2K3QLH6 | A0A2K3QA49 | Replication factor C subunit 4. | N-acetyltransferase eso1. | 0.989 |
TCAP_01678 | TCAP_06435 | A0A2K3QLH6 | A0A2K3Q7P4 | Replication factor C subunit 4. | Replication factor C subunit 2. | 0.999 |
TCAP_01678 | TCAP_06965 | A0A2K3QLH6 | A0A2K3Q689 | Replication factor C subunit 4. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.475 |