node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | Pnec_0110 | Pnec_0108 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | 0.994 |
hisA | hisC | Pnec_0110 | Pnec_1312 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: pnu:Pnuc_0496 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.932 |
hisA | hisD | Pnec_0110 | Pnec_0106 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.978 |
hisA | hisE | Pnec_0110 | Pnec_0113 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pnu:Pnuc_0114 phosphoribosyl-ATP pyrophosphohydrolase. | 0.983 |
hisA | hisF | Pnec_0110 | Pnec_0111 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | Pnec_0110 | Pnec_0105 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.969 |
hisA | hisH | Pnec_0110 | Pnec_0109 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Pnec_0110 | Pnec_0112 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | Pnec_0110 | Pnec_0675 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.870 |
hisA | tatA | Pnec_0110 | Pnec_0115 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.495 |
hisB | hisA | Pnec_0108 | Pnec_0110 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: pnu:Pnuc_0111 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.994 |
hisB | hisC | Pnec_0108 | Pnec_1312 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: pnu:Pnuc_0496 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | Pnec_0108 | Pnec_0106 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisB | hisE | Pnec_0108 | Pnec_0113 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: pnu:Pnuc_0114 phosphoribosyl-ATP pyrophosphohydrolase. | 0.969 |
hisB | hisF | Pnec_0108 | Pnec_0111 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | Pnec_0108 | Pnec_0105 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.978 |
hisB | hisH | Pnec_0108 | Pnec_0109 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | Pnec_0108 | Pnec_0112 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.990 |
hisB | hisZ | Pnec_0108 | Pnec_0675 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.911 |
hisB | tatA | Pnec_0108 | Pnec_0115 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pnu:Pnuc_0109 imidazoleglycerol-phosphate dehydratase. | Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.401 |