STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pnu:Pnuc_0239 glutamate-1-semialdehyde-2,1-aminomutase. (433 aa)    
Predicted Functional Partners:
Pnec_0080
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pnu:Pnuc_0083 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.990
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.986
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.904
Pnec_0260
PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: pnu:Pnuc_0238 rubredoxin-type Fe(Cys)4 protein.
       0.766
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.663
Pnec_0298
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.616
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.548
Pnec_0259
PFAM: putative RNA methylase; THUMP domain protein; KEGG: pnu:Pnuc_0237 putative RNA methylase; Belongs to the methyltransferase superfamily.
       0.540
Pnec_0258
PFAM: conserved hypothetical protein; KEGG: pnu:Pnuc_0236 conserved hypothetical protein 701.
       0.454
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
     
 0.419
Your Current Organism:
Polynucleobacter necessarius
NCBI taxonomy Id: 452638
Other names: P. necessarius STIR1, Polynucleobacter necessarius STIR1, Polynucleobacter necessarius subsp. necessarius STIR1
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